7:00 AM - 7:45 AM
Bridging the Nutritional Gap Between Metabolic and Cardiovascular Disease
(includes complimentary breakfast)
Presented by Scott Minton, Ph.D.
Non-CME symposium sponsored by Nordic Naturals
8:00 AM - 8:30 AM
The Benefits of Meditation and Stress Reduction
Robert D. Willix, Jr., M.D.
CEO, President, Enlightened Living Medicine, Boca Raton, FL
Lecture Description:
Stress has been shown to have a physiologic and perhaps even pathologic effect on the organs of the human body, and leads to increased oxidative stress as well as an increase in corrosive hormones. Adrenaline, cortisol, DHEA, insulin, growth hormone and melatonin levels are all affected by the body’s reaction to stress. Since the advent of the field of psychoneuroendocrine immunology, we now know that the mind has the ability to reduce the effects of stress. There is compelling and increased evidence that the meditative process, which physiologically has been shown to regularize the brainwaves on EEG, seems to be the most effective way of reducing stress. In the early days of stress management, Benson talked about the relaxation response; there are techniques in mindfulness meditation and imagery, along with the values of hypnotherapy. Today, we have enough science to show that, in particular, Transcendental Meditation has been shown to lower peripheral resistance, decrease the complications of heart attacks, and prolong productive life in individuals who have stress related disorders such as hypertension, stroke and heart disease. This lecture will be a demonstration of a technique combining a neurophysiologic meditation with a mantra-driven meditation.
8:30 AM - 9:30 AM
Protecting Your Brain and Keeping it Supple: Nutrients, Herbs, Nootropics, and Mind-Body Practices - Part I
Richard P. Brown, M.D.
Associate Clinical Professor of Psychiatry, Columbia College of Physicians and Surgeons, New York, NY
Lecture Description:
The mechanisms and clinical uses of neuroprotective agents will be discussed. The first hour will cover 5 categories of neuroprotective agents:
1. Cholinergic - Huperzine, Galantamine, Centrophenoxine, Alcar, CDP-choline
2. Nutrients - S-adenosylmethionine (SAMe), Picamilon, Bio-strath, Fish oils
3. Herbs - Rhodiola rosea, Ginseng, Gingko, Sage, Saffron, Vinpocetine
4. Nootropics - Selegiline, Racetams
5. Mind-Body Practices - Biofeedback, Breathing, Movement, Meditation
9:30 AM - 10:30 AM
Protecting Your Brain and Keeping it Supple: Nutrients, Herbs, Nootropics, and Mind-Body Practices - Part II
Richard P. Brown, M.D.
Associate Clinical Professor of Psychiatry, Columbia College of Physicians and Surgeons, New York, NY
Lecture Description:
The second hour will be an experiential program of Movement, Breath Techniques, and Meditation in a sequence designed to raise, circulate, and store vital energy, to enhance autonomic nervous system balance, to improve brain function, and to reduce inflammation.
10:30 AM - 10:45 AM
Break
10:45 AM - 11:30 AM
Gender Differences in Aging: Role Transitions and Depression Prevention in Men and Women
Elisabeth Schramm, Ph.D.
Clinical Psychologist, University Hospital, Department of Psychiatry and Psychotherapy, Freiburg, Germany
Lecture Description:
Aging includes a variety of biological, social, and psychological transitions. Women are confronted with different challenges than men. They go through menopause and the change of their female attractiveness, experience the "empty nest" situation as a loss of one of their major social roles, adopt the burden of home-care for significant others, adapt to a new lifestyle with the retirement of their partner and with entering a new stage of relationship in advanced age.
Women are two-fold more prone to depression than men. Gender differences are explained multi-factorially – on the one hand by “biological sex," particularly sexual hormones, and on the other hand by “psychosocial gender” including all attributed and acquired roles in relationships, family, profession and economical structures. Whereas in men breakdowns, burnout and depressed states are typically associated with problems at work, women attribute them to social role changes and interpersonal conflicts (Schneider et al, 2008).
Coaching and therapeutic approaches for prevention or treatment should therefore be gender-sensitive, as it is for example reflected in Interpersonal Psychotherapy, an evidence based short-term approach which addresses gender differences in a specific way.
11:30 AM - 12:15 PM
Review of Factors Influencing Alzheimer’s Disease Onset: Can We Delay Onset and Therefore Prevent Alzheimer’s?
Gayatri Devi, M.D.
Clinical Associate Professor, New York University School of Medicine
Director, New York Memory and Healthy Aging Services
Lecture Description:
We will review evidence based risk factors leading to Alzheimer’s, the most common type of dementia. We will then discuss how to address prevention. Additional data on preventing stroke related dementia, the second most common type of dementia, will be presented.
12:15 PM - 1:30 PM
Lunch Break
12:15 PM - 1:15 PM
Endothelium Glycocalyx and Its Role in the Aging Process
(includes complimentary lunch)
Presented by Hans Vink, Ph.D. and Jay Udani, M.D.
Non-CME symposium sponsored by Vascular Health Sciences
1:30 PM - 2:15 PM
Evidence-Based Plan to Slow Cognitive Decline and Enhance Cognitive Function
Steven C. Masley, M.D., FAHA, FACN, FAAFP, CNS
President, Masley Optimal Health Center, St. Petersburg, FL
CEO, Heart Tune-Up, LLC
Medical Director, Ten Years Younger Program™
Clinical Assistant Professor, University of South Florida, Tampa, FL
Special Program Instructor, Eckerd College and the University of Tampa
Lecture Description:
This presentation will clarify modalities to measure cognitive function and causes of accelerated cognitive decline including: mercury toxicity, inactivity, and nutrient deficiencies. Evidence-based and theoretical modalities to enhance cognitive performance will be reviewed, including exercise and various nutriceuticals.
2:00 PM - 7:00 PM
Exhibits Open
2:15 PM - 3:00 PM
The Role of Sleep for a Healthy Brain
Preetam Schramm, Ph.D., RPSGT
Consultant, MyCardio LLC, Thornton, CO
Medical Advisory Board, SleepTech Enterprises, LLC, Wayne, NJ
Lecture Description:
Life expectancy has increased in the United States to over 78 years and at the same time the prevalence of degenerative brain disorders with associated sleep complaints (e.g. Alzheimer's disease) is growing. Keeping the brain healthy to improve long term general health involves maintaining good quality sleep. It is known that the brain repairs itself during non-rapid eye movement sleep. The repair process is associated with concomitant decrease in blood pressure, immune system enhancement, synchronous cortical neuronal firing, localized neuronal slow wave sleep, dendritic "rewiring" and limbic system influenced respiratory sinus arrhythmia. Evidence exists suggesting the brain consolidates learned experiences from the previous wake state into memories in rapid eye movement sleep. Poor and fragmented sleep is an early component of Alzheimer’s disease and mice models show similar sleep disturbances before evidence of amyloid plaque deposition. These illustrations indicate how closely sleep and synaptic machineries are related creating the possibility of restoring synaptic mechanisms through sleep management as a therapeutic avenue. The universality of sleep and its critical role in neuronal plasticity makes it essential to maintain its long-term stability. Integration of sleep assessment into a clinical practice begins with having appropriate tools to assess sleep quality objectively in the same way patient assisted tracking of weight; blood pressure and glucose measures are
performed. The physician incorporates the sleep data to guide the patient’s decisions related to sleep habits, life style changes, nutrition and exercise. NOTE: WILL INCLUDE A SLEEP STUDY ON UP TO 10 SELECTED ATTENDEES TO BE REPORTED ON DURING THIS LECTURE.
Some suggestions for volunteers:
CPAP user - to determine if the pressure is optimal;
Wine/alcohol intake before bed - to show the effect of alcohol on sleep quality;
Coffee intake before bed - demonstrate caffeine effect on sleep quality;
Prior sleep lab evaluation for restless leg syndrome or periodic limb movements - to compare.
3:00 PM - 3:45 PM
Break - Exhibits Open
3:45 PM - 4:30 PM
Oxytocin and the Aging Brain
Jorge Flechas M.D., MPH
Private Practice, Hendersonville, NC
Lecture Description:
As all of us age, oxytocin levels in the brain are dropping. Oxytocin is the number one neuropeptide in the brain. Much research has been done on oxytocin's role in the brain. The function of the brain in autistic children (who have very little oxytocin) is very much what all of our brains will behave like as we age. Dopamine is a stimulator of oxytocin production. Some of the Parkinson's patient brain functions are due to oxytocin insufficiency. A focus review of oxytocin and its role for normal brain function will be done. Current evidence shows that the levels of CNS oxytocin go down with aging. Low levels of oxytocin are associated with increased muscle pain, loss of short term memory, loss of love, loss of happiness, loss of sexual function and desire. Parkinson's disease Is associated with low oxytocin.
4:30 PM - 5:30 PM
Healthy Brain Aging: Quantifying and Tracking Change
Gayatri Devi, M.D.
Clinical Associate Professor, New York University School of Medicine
Director, New York Memory and Healthy Aging Services
Lecture Description:
A review of the neuroimaging, neurocognitive and other biomarker features that are associated with healthy brain aging.
Will also include a 15 minute cognitive testing workshop for participants.
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Bridging the Nutritional Gap Between Metabolic and Cardiovascular Disease
(includes complimentary breakfast)
Presented by Scott Minton, Ph.D.
Non-CME symposium sponsored by Nordic Naturals
8:00 AM - 9:15 AM
Introduction to Basic Principles of Exercise Physiology
Jeffrey P. Leake, M.D., ISSA-CPT
Senior Institute Physician, Course Director for Physician Training and Certification in Age Management Medicine, Cenegenics Medical Institute, Las Vegas, NV
Lecture Description:
Review basic physiology of exercise, components of fitness, and adaptations to exercise. Upon completion the physician will understand the basic principles of exercise physiology and identify the components of fitness.
9:15 AM - 10:15 AM
Assessing Fitness Levels in the Clinical Setting
Rudy M. Inaba
Director, Nutrition & Exercise, Cenegenics Elite Health
Instructor, AMMEF Certification Course
Lecture Description:
A guided tutorial of assessing fitness levels by utilizing a series of diagnostic assessments in the clinical setting using metabolic and non-metabolic analyses. Collected data provides insight towards the development of cardiovascular exercise prescription, in addition to risk factor assessment in measured populations.
10:15 AM - 10:30 AM
Break
10:30 AM - 11:30 AM
Interpreting and Understanding the Fitness Assessment
Jeffrey P. Leake, M.D., ISSA-CPT
Senior Institute Physician, Course Director for Physician Training and Certification in Age Management Medicine, Cenegenics Medical Institute, Las Vegas, NV
Lecture Description:
Lecture will describe the components of and how to conduct a needs analysis of a patient including a review of cardio-respiratory fitness and its relation to mortality. Upon completion the physician will understand what the components of a fitness assessment are and how fitness relates to mortality.
11:30 AM - 12:15 PM
Exercise Diagnosis & Prescription Model: Development of an Individualized Treatment Plan
Joseph F. Signorile, Ph.D.
Professor, Department of Kinesiology and Sport Sciences, University of Miami, Miami, FL
Lecture Description:
The aging process affects all of the systems of the body reducing our capacities to live independently and safely, and often our health, well-being and joie de vivre. Scientists and clinicians have often discussed the multi-pill that contains all the ingredients that address the declines in health and function seen with aging. More and more one such pill jumps to the forefront of the discussion, and it’s called exercise. Unfortunately, we do not all age the same way and each of us has his or her unique set of needs that dictate the best exercise intervention. Based upon his research and publications this lecture provides a unique look at how to address the multi-faceted needs of each individual using functional diagnoses to design targeted exercise programs. The talk describes how to structure a periodized training program that provides the most effective mix of work and recovery and explains Dr. Signorile’s concept of translational training as an effective tool to translate physical improvements into improvements in daily living.
12:15 PM - 1:30 PM
Lunch Break
12:15 PM - 1:15 PM
Endothelium Glycocalyx and Its Role in the Aging Process
(includes complimentary lunch)
Presented by Hans Vink, Ph.D. and Jay Udani, M.D.
Non-CME symposium sponsored by Vascular Health Sciences
1:30 PM - 2:15 PM
Treatment Plan Development: Resistance Training
Jeffrey P. Leake, M.D., ISSA-CPT
Senior Institute Physician, Course Director for Physician Training and Certification in Age Management Medicine, Cenegenics Medical Institute, Las Vegas, NV
Lecture Description:
Review the concept of periodization and how to advance a resistance training program. Upon completion the physician will understand periodization, the benefits of a periodized vs. non-periodized program, and how to advance a training program regimen.
2:00 PM - 7:00 PM
Exhibits Open
2:15 PM - 3:00 PM
Treatment Plan Development: Anaerobic Interval Training
Jeffrey P. Leake, M.D., ISSA-CPT
Senior Institute Physician, Course Director for Physician Training and Certification in Age Management Medicine, Cenegenics Medical Institute, Las Vegas, NV
Lecture Description:
Describe VO2 testing, its interpretation as a diagnostic screening exam for heart disease and its utility in constructing an aerobic training program. Upon completion the physician will be able to interpret a VO2 test, and write an interval training program based upon those results.
3:00 PM - 3:45 PM
Break - Exhibits Open
3:45 PM - 4:30 PM
Treatment Plan Development: Sprint Interval Training with Demonstration
Kevin M. Finnegan, M.S.
Director, Product Formulations, Cenegenics Global Health
Lecture Description:
High intensity interval training presentation using a cycle ergometer to demonstrate constant exercise within anaerobic metabolism. This presentation will tie together the concepts of pulmonary exchange within the lungs and the ability to achieve this metabolism through specific training sessions.
4:30 PM - 5:30 PM
An Exploration of Exercise Training Data in the Older Adult
David Spierer, Ed.D.
Associate Professor of Exercise Science & Director, Human Performance Laboratory, Division of Athletic Training, Health and Exercise, Long Island University, New York
Lecture Description:
The age-related decline of aerobic fitness, strength, power, balance and coordination hinders one’s performance in functional activities of daily living and thus alters quality of life. Despite the wealth of epidemiological data that suggest physical activity reduces the risk of various age-related morbidities and all-cause mortality the requisite amount of activity, which produces improvements in the aforementioned components is still unclear. Some of the research suggests a threshold of intensity commensurate with moderate-physical activity guidelines to achieve and preserve health related benefits and other work purports the necessity of a more intense stimulus. This purpose of this lecture is to review the physiological responses to acute exercise, identify key adaptations to exercise training and discuss sports performance and appropriate program design in an older adult population.
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Bridging the Nutritional Gap Between Metabolic and Cardiovascular Disease
(includes complimentary breakfast)
Presented by Scott Minton, Ph.D.
Non-CME symposium sponsored by Nordic Naturals
8:00 AM - 9:00 AM
How to Incorporate Nutritional Supplements into Your Clinical Practice
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
Lecture Description:
Incorporating supplements into a medical practice is not as complicated as one may think. We have spent a number of previous lectures documenting the evidence-based medical necessity for the use of supplements. During this lecture Dr. DeSilva will introduce you to the options available for adding supplements to your practice and show you how to streamline the process and add as a revenue stream.
9:00 AM - 10:00 AM
Compounding: Dosage Forms & Dosing Solutions
Terri Weisenbach, R.Ph.
Partner & Director of Pharmacy Services, Belmar Pharmacy, Lakewood, CO
Lecture Description:
Lecture will cover dosage forms and the advantages and disadvantages of each form, including options when patients are not receiving the desired response or obtaining targeted serum levels. In addition there will be a discussion on how patient variability will effect levels and symptom relief. These will include such variables as weight, activity level, time of last dose, half life and duration of action, pm vs am dosing, etc. Lecture will also cover trends in compounding requests, progesterone dosing, and frequently asked questions by physicians and their staff.
10:00 AM - 10:30 AM
Insurance Issues in Clinical Age Management Medicine Practice
John J. Rush, M.D., FACEP, MBA, MHA
Age Management Physician, Washington, D.C.
Founder & Chairman, Longevity Physicians Insurance Company
John Palmer
Vice President, Oceanus Insurance Company, Charleston, SC
Lecture Description:
Whether you're starting an age management medicine practice or already have a growing one and want to protect it, this session will present a lively discussion about all the things that can (and some will!) go wrong. Of course you’re covered for malpractice insurance, but what about general liability insurance? Without adequate insurance, your practice’s financial health could be seriously compromised. Imagine, for example, if you had to deal with any of these situations:
• Several of your employees file a lawsuit alleging discrimination.
• A “trusted employee” embezzles from the practice.
• The government investigates alleged overbilling of Medicare services.
• An employee sues over alleged pension mismanagement.
• A hacker demands payment under a threat to publicize proprietary patient information.
• A disgruntled employee carries out a violent attack in the workplace.
We’ll discuss all of these and more of the options available to you:
• Crime Insurance
• Directors and Officers Liability Insurance
• Fiduciary Liability Insurance
• Kidnap/Ransom and Extortion Insurance (including complimentary crisis management services)
• Workplace Violence Expense Insurance
10:30 AM - 10:45 AM
Break
10:45 AM - 11:30 AM
Motivating Patients to Get Motivated During Age Management Therapy
Jennifer Zerling, M.S., CPT
Exercise and Nutrition Director, Cenegenics of Beverly Hills, CA
Lecture Description:
Presentation provides insight of how to increase self-motivation within a patient to develop positive adaptations for a healthier lifestyle. This presentation bridges the information and action steps needed to successfully motivate patients to commit to healthy age management practices.
11:30 AM - 12:15 PM
Personalized Laboratory Testing: A Means of Practice Development
Filomena F. Trindade, M.D., MPH
Private Practice, Capitola, CA
Professor, Fellowship in Metabolic & Nutritional Medicine, Morsani School of Medicine, University of South Florida
Faculty, Hormone Module, Institute for Functional Medicine, Gig Harbor, WA
Lecture Description:
This presentation is designed to provide an understanding of the benefits that personalized laboratory testing brings to clinical practice. For physicians, these value-added specialty testing solutions support improved patient outcomes; improved ability to diagnose & treat chronic conditions; and improved clinical practices & higher revenue. Join Dr. Trindade as she discusses the didactic and practical (case study) merits of offering personalized laboratory evaluations in the clinical setting.
12:15 PM - 1:30 PM
Lunch Break
12:15 PM - 1:15 PM
Endothelium Glycocalyx and Its Role in the Aging Process
(includes complimentary lunch)
Presented by Hans Vink, Ph.D. and Jay Udani, M.D.
Non-CME symposium sponsored by Vascular Health Sciences
1:30 PM - 2:15 PM
Physician Benefits of Practicing Age Management Medicine
George Weiss, M.D.
Owner & Medical Director, Wellness and Longevity Medical Group of La Jolla, Inc., La Jolla, CA
Lecture Description:
In an ever changing medical climate where insurance is king—robbing patients of precious time with their practitioners and leaving physicians and staff overloaded and overworked with little return at the end of the day—more and more frustrated physicians are turning to a new medical model, converting their present insurance based practice of disease diagnosis and treatment, to a cash based preventative age management practice, resulting in an integrative practice that is beneficial to both patient and physician. The future of medicine is walking a precarious line where balance is the key to success and longevity.
2:00 PM - 7:00 PM
Exhibits Open
2:15 PM - 3:00 PM
Practice Development; Growing Your Practice
James Powell
Corporate Sales Consultant and Trainer, Cenegenics Medical Institute
CEO, Medical Business Consulting
Lecture Description:
Attendees will learn how to identify age management patients, establish an effective agenda with the patient, learn about patient needs and understand how to build rapport and position your solution to match the patient’s needs.
3:00 PM - 3:45 PM
Break - Exhibits Open
3:45 PM - 4:45 PM
Legal Issues Related to Marketing and Billing Your Services
Jane Pine Wood, Esq.
Attorney at Law, McDonald Hopkins, LLC, Dennis, MA
Lecture Description:
Lecture will cover legal issues for clinicians regarding need-to-know legal implications for marketing and in billing of services.
4:45 PM - 5:30 PM
Panel Discussion: Getting Started in Age Management Medicine
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
John J. Rush, M.D., FACEP, MBA, MHA
Age Management Physician, Washington, D.C.
Founder & Chairman, Longevity Physicians Insurance Company
James Powell
Corporate Sales Consultant and Trainer, Cenegenics Medical Institute
CEO, Medical Business Consulting
Lecture Description:
One of the most frequently asked questions by attendees to the Age Management Medicine Conference is, “How do I get started?“ During this Practice Management session, attendees have the opportunity to hear from and ask questions of our panel. The panel reflects two general categories of our attendees: those that have an existing ”mainstream" medical practice and wish to add elements of Age Management Medicine to that practice, and clinicians who wish to devote their entire practice or a substantial portion of their practice to Age Management Medicine.
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Estrogen in Men: Good, Bad or Indifferent? An evidence-based review for
optimal health
(includes complimentary breakfast)
Presented by Neal Rouzier, M.D.
Non-CME symposium sponsored by MedQuest Pharmacy
8:00 AM - 8:05 AM
Opening Remarks
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
8:05 AM - 8:30 AM
Presentation of the Alan P. Mintz, M.D. Award for Clinical Excellence in Age Management Medicine
8:30 AM - 9:30 AM
The Etiology of Aging is Now Understood
Leonard Hayflick, Ph.D.
Professor of Anatomy, University of California, San Francisco, CA
KEYNOTE PRESENTATION
Lecture Description:
The belief that aging is still an unsolved problem in biology is no longer true. To understand this belief it is necessary to define the four phenomena that characterize the finitude of life: aging, the determinants of longevity, age-associated diseases, and death. Age changes can occur in only two fundamental ways: either as the result of a purposeful program driven by genes or by stochastic or random, accidental molecular events. The weight of evidence indicates that a gene-driven program does not govern the aging process; the stochastic or random loss of molecular fidelity does. Potential longevity is determined by the energetics of molecules present after reproductive maturation including those that compose the repair machinery involved in turnover, synthesis, and maintenance. The repair and synthesis processes that exceed the appearance of dysfunctional molecules prior to reproductive maturity then shifts so the spread of energy described in The Second Law of Thermodynamics that creates an excess of dysfunctional molecules, begins to exceed repair capacity and the thermodynamic instability characteristic of the aging process begins. The maintenance, repair and synthetic pathways that maintain the fidelity of molecules produced before and after reproductive maturity determine longevity. Unlike the stochastically driven aging process, longevity determination is governed by the genome. Furthermore, the aging process is fundamentally distinct from age associated diseases.
Unlike any disease, age changes (a) occur in every multi-cellular animal that reaches a fixed size in adulthood, (b) cross virtually all species barriers, (c) occur in all members of a species only after the age of reproductive maturation, (d) occur in all animals removed from the wild and protected by humans even when that species probably has not experienced aging for thousands or even millions of years, (e) occur in virtually all animate and inanimate matter, and (f) have the same universal molecular etiology, that is, thermodynamic instability. Unlike aging, there is no disease or pathology that shares these six qualities. Because this critical distinction is rarely understood, the enormous imbalance of resources spent more on studying age associated disease than doing research on the fundamental biology of aging cannot be expected to increase our knowledge of aging.
9:30 AM - 10:15 AM
Dispelling the Myths: Top 10 Medical Myths Surrounding Age Management Medicine
Michale J. Barber, M.D.
CEO, CMO, Better Life Carolinas, Charleston, SC
Lecture Description:
This lecture will focus on several common misconceptions or misunderstanding in medicine, specifically in the area of Age Management Medicine that will be debunked based on literature review and clinical experience.
10:15 AM - 11:00 AM
Break / Visit Exhibits
11:00 AM - 12:00 PM
Genetic Scrutiny: Perception of Disorders of Aging
Florence Comite, M.D.
CEO & Founder, Comite Center for Precision Medicine, New York, NY
Member, AMMG Conference Planning Committee
Lecture Description:
Genetic screening is increasingly available; it is a natural extension of Age Management Medicine. Obtaining the genetic make-up of individuals can help to identify potential disorders of aging. However, the genetic blueprint is not absolute, nor is it a predestined outcome. Since this is generally poorly understood by most, the clinician must be comfortable with the interpretation of genetic testing before embarking on diagnostic screening. Patients deserve a solid understanding of the relationship between their genes and disorders of aging. It is vital that the clinician is prepared to balance, discuss, and position the possible outcomes before testing and with the reported results. Overall, screening adds much to our ability to identify underlying influences that might tilt the scales toward various disorders of aging. At the same time, it strengthens our ability to manage and motivate successfully. Further, it allows the clinician to set interventional priorities and weigh the risk-benefit scale of options. This leads to more precise guidance with respect to subsequent diagnostic tests and procedures as well as interventions, ranging from lifestyle to supplements and medications.
12:00 PM - 1:15 PM
Lunch Break
12:00 PM - 1:00 PM
Lunch Symposium: Physician Opportunities in Age Management Medicine: Your Path to a Successful Age Management Medicine Practice
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
Non-CME Symposium Sponsored by Cenegenics Medical Institute
Open to all attendees and includes a complimentary lunch
1:15 PM - 2:00 PM
Does Iodine Cause or Prevent/Treat Autoimmune Thyroid Disorders?
David Brownstein, M.D.
Medical Director, Center for Holistic Medicine, West Bloomfield, MI
Lecture Description:
This lecture will discuss iodine’s role in preventing and treating autoimmune thyroid disorders. Iodine is an essential element for the body and the thyroid gland. When iodine levels are deficient, it sets the stage for disruption of thyroid hormone production. Specific recommendations on how to safely incorporate iodine therapy into the autoimmune thyroid patient’s regimen will be discussed. Finally, this lecture will show you conditions where it is not advantageous to use iodine.
2:00 PM - 2:45 PM
Hormones, Cognitive Dysfunction, and Depression in Older Adults
Louis B. Cady, M.D.
Adjunct Assistant Professor of Psychiatry, Department of Psychiatry, Indiana University School of Medicine
Founder & President, Cady Wellness Institute, Newburgh, IN
Lecture Description:
Foggy thinking, forgetfulness, confusion, uncertainty and depression are the all too common catalogue of complaints practitioners hear from patients in the growing elderly of the baby boomer generation. Former clear thinkers, good organizers, high functioning and thoughtful individuals are reduced to paper task lists, repeatedly rereading information and experiencing indecision, as well as tears and depression as their previously well-functioning brains seem to lose emotional calibration as well as details, the big picture, and the usual route to the grocery store. The impact of hormone imbalances on cognitive function and affective dysfunction is increasingly documented in the medical literature, yet there appears little consensus in common medical practice in terms of points of diagnosis and intervention. A poor quality diet, lifestyle pressures and high stress can also have a significant disrupting effect on physiological and hormonal balance, which can then exert a feed-forward effect onto a steadily exacerbating spiral of cognitive dysfunction and evolving depression. This presentation will explore in more detail the complex and powerful relationships between hormones and neurotransmitters, identifying which imbalances impair cognitive function, what behaviors compound the situation, and what are the options for restoring a potent, powerful brain.
2:45 PM - 3:15 PM
Break / Visit Exhibits
3:15 PM - 4:00 PM
New Advances in Cardiac Regeneration – Stem Cells and Growth Factors and their Relationship to Age Management Medicine
George C. Shapiro, M.D., FACC
Adjunct Assistant Professor Clinical Medicine, New York Medical College, Valhalla, NY
Founding Partner, Cenegenics, New York City
Member, AMMG Conference Planning Committee
Lecture Description:
One of the most urgent clinical needs of this century is the development of regenerative therapeutic strategies to reverse the progression of advanced heart failure to improve longevity. Recently new targets and strategies for regenerative therapies have been developed. The results from recent clinical trials of adult stem cells, together with fundamental scientific advances in cardiac stem cell and regenerative biology, are beginning to yield potential. My focus will be on new scientific discoveries related to intrinsic cardiac regeneration, renewal factors that can trigger regeneration, and tissue-engineering technology and how they all relate to the field of Age Management Medicine.
4:00 PM - 4:45 PM
Beyond Cholesterol: Advanced Lipid Panels in the Clinical Setting
Cesar M. Pellarano, M.D.
Preventive Cardiologist, Miami, FL
President, Founding Partner and Chief Medical Officer, Hillstar Health LLC, Miami, FL
Lecture Description:
Advanced lipid panels have been available for years in several forms and by different companies. Over 50% of heart attack victims have normal cholesterol values. Advanced lipid panels offer a breakdown of the lipid particles to better stratify the cardiovascular risk. LDL or "bad" cholesterol is made up of several sized particles. We know that the small LDL III and LDL IV are the most atherogenic. Likewise not all HDL is cardio protective. Only the buoyant HDL offers protection. This lecture will detail the use of these panels in the clinical setting.
4:45 PM - 5:30 PM
Genetic Testing: How It All Fits Into Clinical Practice
H. Robert Superko, M.D., FACC, FAHA, FACC
Clinical Professor, Mercer University School of Pharmaceutical Sciences, Atlanta, GA
VP, Chief of Medical Affairs, Celera Corporation, Alameda, CA
Lecture Description:
Cardiovascular disease remains the leading cause of morbidity and mortality in the USA. The approximate 25% relative risk reduction consistently reported in clinical trials achieving LDL-C reduction with statin medications is actually only a 3% absolute risk reduction. There is a need to go beyond standard risk factors to diagnose the potential etiology in individual patients, and to create the most successful individual therapeutic approach. Genetic cardiology has exploded in the past decade and tests currently exist that independently predict CVD events in both primary and secondary prevention, guide individualized therapy, and assist in identification of first degree relatives at very high risk for CVD events. Practical, specific disorders and response to treatment will be identified and case studies presented.
6:30 PM - 7:30 PM
Bringing Integrated Health to Life
Presented by Michael Bianco, C.E.O., Renua Medical
7:00 AM - 7:45 AM
Case Study: A Successful Age Management Practice
(includes complimentary breakfast)
Presented by Jerry Fortunato, MBA
Non-CME symposium sponsored by PhysioAge
8:00 AM - 8:45 AM
Conventional Medical Care vs. Age Management Medical Care: Case Studies of
Two Patients With Advanced Metabolic Syndrome
Jeffry S. Life, M.D., Ph.D.
Clinic Physician, Apeiron, Charleston, WV
Board Certified, Family Medicine
Diplomate, American Board of Family Practitioners
Fellow, American Academy of Family Physicians
Lecture Description:
Lecture consists of a detailed description of the changes in cardiovascular
risk factors, psychological status, energy levels, sexual function, body
composition, and fitness levels of two patients, a 42-year-old and a 53-year-
old male, who elected to change their traditional medical care to age
management medical care. Both patients have severe metabolic syndrome and
have been followed by cardiologists who have employed traditional American
cardiology care. The 42-year-old had an MI one month prior to starting the
age management program. Both men have type 2 diabetes and hypertension.
These patients appeared on the Dr. Phil show in early May just before
starting an age management program. Dr. Phil will be doing a follow-up show
with these two men in late October or early November, six months after they
switched their care from their cardiologists to an age management medicine
program, to assess their overall status in their attempts to reverse their
downhill course toward advanced cardiovascular disease.
8:45 AM - 9:30 AM
Effect of a Physician Supervised Exercise and Nutrition Program with Hormone Substitution on Cardiopulmonary Capacity
Ernst R. Schwarz, M.D., Ph.D.
Professor of Medicine, Cedars Sinai Medical Center at UCLA
Lecture Description:
We describe the results of a retrospective data analysis in self-referred male patients to a commercially available age-management program. The program consisted of a physician-supervised exercise and nutrition program with androgen substitution in cases with low testosterone levels and clinical signs of andropause. The data of basic and follow up myocardial oxygen consumption testing at one year using cardiopulmonary exercise testing are presented. This is the first study evaluating functional and hemodynamic parameters as a result of an age management program.
9:30 AM - 10:15 AM
An Evidence Based Review Demonstrating Longevity Benefits vs. Increased Mortality: Do Hormones Truly Make You Live Longer or Die Sooner?
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
Healthy patients are more concerned with improving quality of life and feeling better rather than living longer. Nevertheless the term “Longevity Medicine” is commonly utilized to describe hormone replacement rather than “Anti-aging.” Medical journalism frequently denigrates hormone replacement without considering the plethora of data and studies supporting the optimization of hormones. This review explores the world’s literature as it pertains to longevity, wellness, which hormones increase longevity and which ones shorten, which ones cause cancer and which ones protect. Once one understands the scientific literature, it makes it unconscionable not to optimize all hormone levels, both for ourselves and for our patients. Where would you like your levels to be?
10:15 AM - 10:45 AM
Break / Visit Exhibits
10:45 AM - 12:00 PM
Rethinking the Hypothalamic-Pituitary-Gonadal Axis Underlying Mechanisms, Novel Diagnostic Protocols and Alternative Treatment Options for Male Hypogonadism
Karlis C. Ullis, M.D.
Private Practice, Sports Medicine and Preventive Medicine Group, Santa Monica, CA
Alan Gurler, M.S.
Personal Fitness Trainer, AG Fitness, West Los Angeles, CA
Lecture Description:
Classic clinical age management practice has primarily focused on long-term testosterone replacement therapy (TRT) for optimal aging. It has become increasingly apparent that the age of hypogonadism is occurring at younger ages and symptoms (e.g. Low Testosterone Syndromes) may be present despite specific T serum values being within so-called normal laboratory reference ranges. There is a gradient of maleness and androgenicity which has recently been elucidated. The maleness gradient is associated with androgen receptor sensitivity differences in men. This gradient may explain long-term effects of androgens throughout a male's lifetime. Many middle-aged or younger men no longer want sole treatment with long-term TRT for low testosterone values and/or symptoms. Because of the increasing prevalence of TRT it is important to revisit the misconception that only supraphysiologic doses of testosterone have the capacity to suppress endogenous testosterone production, spermatogenesis and other normal male physiological processes. We need an understanding that not all males are the same. This presentation provides novel protocols to clinically determine where defects are within the H-P-G axis of Low T Syndromes. Androgen receptor differences will be discussed for future clinical applications. Diagnostic and therapeutic schemes will be presented to determine and provide appropriate therapy to avoid infertility, testicular atrophy, pituitary issues, and other dysfunctions associated
with long-term dependence on TRT.
12:00 PM - 1:15 PM
Lunch Break
12:00 PM - 1:00 PM
Lunch Symposium - BioG MicroTabs: Ingredients for Personalized Nutrition and Health
Julian Blumenfeld, M.D.
Mr. Wolfgang Roehr
Open to all attendees and includes a complimentary lunch
Non-CME symposium sponsored by Roehr Pharmaceuticals
1:15 PM - 2:15 PM
Vaginal Rejuvenation
Anna Cabeca, D.O., FACOG, ABAARM
Medical Director, Vida Pura Health, Golden Isles Medical, Inc., St. Simons Island, GA
Lecture Description:
Vaginal health is a subtle topic but with a big impact in women’s lives. Creating healthy vaginal tissue through local and systemic therapies is transforming for women and their relationships and sexual health. Therapeutic regimens will be discussed.
2:15 PM - 3:00 PM
Female Libido, Arousal, Performance
Jay E. Mattingly, M.D.
Tenured Associate Professor of Anesthesiology, Clinical Director, Dept. of Anesthesiology, University of Tennessee Center for Health Sciences, Memphis, TN
President, Rejuvenation Medicine Institute
Lecture Description:
In this 21st century sexually-charged media milieu, Hypoactive Sexual Desire Disorder (HSDD) is the shadow entity in 40% or more of women's lives that has them staring in the mirror feeling inadequate and empty. The forces challenging women's sexual desire, their difficulties with arousal, and their struggles to 'get there' are explored and elucidated. Solutions pertinent to the nuances of each challenge are suggested by relevant literature, along with delving into the potential abundant harvest of a rich sexual relationship with their committed partner.
3:00 PM - 3:45 PM
Break / Visit Exhibits
3:45 PM - 4:45 PM
Association of Age and Epigenetic Changes with Multiple Autoimmune Reactivity
Aristo W. Vojdani, Ph.D., M.Sc., C.L.S.
Founder, CEO and VP of Research and Development, Immunosciences Lab., Inc., Los Angeles, CA
Lecture Description:
Aging of the immune system, or immunosenescence, is characterized by a decline in the immune function and the presence of low-grade chronic inflammation. This decline in immunocompetence with age and along with low-grade chronic inflammation is accompanied by an increase in the incidence of autoimmune diseases.
The American Autoimmune Related Disease Association reports that 53 million Americans have autoimmune disease. Autoimmunity is thought to result from interaction between genetics and environmental triggers. However, since <10% of individuals with genetic susceptibility to various autoimmune disorders develop the disease during their lifetime, accumulated evidence indicates that initiation of autoimmune diseases can be impacted by environmental factors.
This presentation examines:
1) the contribution of selected chemicals such as drugs, heavy metals, pesticides, solvents, cosmetics, smoking, and biologicals, including bacteria, viruses, parasites, and dietary proteins such as gluten and casein in autoimmunity;
2) mechanisms by which each of these factors participate in the induction of autoimmunities. In addition to age, epigenetic changes have also been observed to occur in response to environmental exposure, in particular, DNA methylation and histone acetylation accumulation during aging can contribute to autoimmunity risk.
3) various biomarkers, in particular predictive antibodies against different tissue antigens, as well as against the environmental
triggers for very early detection of autoimmune reactivity.
As stated in my earlier manuscripts, molecules called predictive autoantibodies appear in the blood years before people show symptoms of various disorders. Tests that detected these molecules could warn of the need to take preventive action. Researchers and clinicians should ask the questions, why does the human body react to its own antigens, which results in the production of potentially harmful autoantibodies? The cause may be due to environmental factors such as bacterial or viral infections, or haptenic toxic chemicals binding to human tissue, causing modifications of self-antigens and the subsequent production of autoantibodies. Without the identification of factors such as infections, dietary proteins and xenobiotics as major instigators of autoantibodies, clinicians will not be able to take preventive action. Therefore, early detection of antibodies against various tissue antigens and the identification of the environmental triggers involved in the induction of autoimmunity can facilitate a proper and timely intervention. This would make a significant difference in the management of autoimmune disease and prevent or ameliorate the many years of suffering associated with multiple autoimmune reactivity syndrome.
4:45 PM - 5:30 PM
Recent Developments in the Biology of Telomere
William H. Andrews, Ph.D.
President & CEO, Sierra Sciences, Reno, Nevada
Lecture Description:
In the last 20-30 years, there has been a tremendous upsurge in our scientific knowledge about why there is a theoretical 125-year limit on the human lifespan. The research that will eventually defeat this limit is underway. Clinical data and animal data, including several very recently published papers, suggest the answer is most likely telomeres. The past five years have provided a steady stream of evidence that a small-molecule compound that induces telomerase could slow, stop, or reverse the human aging process without causing complications such as an increased risk of cancer. A landmark experiment two years ago reversed symptoms of human-like aging in mice. The first telomere-lengthening nutraceuticals are already commercially available and providing evidence that the future may be here today. And even more recent discoveries offer new treatment approaches in the very near future.
7:00 AM - 7:45 AM
Unlocking the Secrets of Aging, Telomeres, Telomerase Activation and TA-65
Presented by Noel Thomas Patton, CEO and Founder of Telomerase Activation Sciences, Inc.
(includes complimentary breakfast)
Non-CME symposium sponsored by T.A. Sciences
8:00 AM - 9:00 AM
The 5 Most Common Workout Injuries: Using Biologic Therapies to Keep Your Middle-Aged Weekend Warrior Going
Christopher Centeno, M.D.
Medical Director, Centeno-Schultz Clinic, Broomfield, CO
Member, AMMG Conference Planning Committee
Lecture Description:
So your hormone optimized age management patient wants to hit the gym hard and quickly gets injured—threatening the age management program. What are the 5 most common musculoskeletal injuries and how can you use newer biologic therapies to heal them without the extensive downtime of surgery? Platelet rich plasma, platelet lysate, and stem cells will be reviewed.
9:00 AM - 10:00 AM
Current Advances in Orthopedic Sports Medicine and How They Can Impact the Aging Athlete
Jonathan L. Glashow, M.D.
Clinical Associate Professor & Co-Chief, Sports Medicine Service, Dept. of Orthopaedic Surgery, Mount Sinai Medical Center, New York, NY
Lecture Description:
This lecture will focus on advances in current “All Arthroscopic ACL Reconstruction,” “Arthroscopic Rotator Cuff, Labral and Biceps Surgery” and “Cartilage Transplant Surgery” and how these new technologies, once reserved for professional athletes, have transformed the weekend warrior's ability to make a more complete recovery, incorporating the use of biologics and accelerated rehabilitation techniques.
10:00 AM - 10:15 AM
Break
10:15 AM - 11:00 AM
Toxins: How They Contribute to Aging and Chronic Disease
Filomena F. Trindade, M.D., MPH
Private Practice, Capitola, CA
Professor, Fellowship in Metabolic & Nutritional Medicine, Morsani School of Medicine, University of South Florida
Faculty, Hormone Module, Institute for Functional Medicine, Gig Harbor, WA
Lecture Description:
Recently and over the last few years there has been much more scientific data on environmental toxins’ effect our health. We now have information on toxins interfering with blood sugar and cholesterol metabolism, causing insulin resistance, autoimmune problems, diabetes, obesity, hormone disruption, and contributing to disease in general. However, there has been little focus on how we can detoxify. Indeed detoxification is complex. To me, it is like climbing a very high mountain. One must prepare for it and do it cautiously and stepwise. First, we have to assess the terrain, look for the underlying root causes, develop an individualized detoxification protocol and then take the appropriate steps to make sure the body is able to process the load once detoxification is begun. A practical functional medicine approach includes: 1. Reducing exposure as much as possible, 2. Decreasing total body burden, 3. Promoting detoxification and 4. Promoting elimination. Phase I and phase II detoxification support must be individualized for each patient taking into account specific genomic variations.
11:00 AM - 12:00 PM
Emerging Concepts in the Diagnosis and Treatment of Hypothyroidism
Kent Holtorf, M.D.
Owner & Medical Director, Holtorf Medical Group Affiliate Centers
Founder & Medical Director, National Academy of Hypothyroidism
Lecture Description:
The lecture will review the medical literature and present data demonstrating that hypothyroidism causes or contributes to a wide range of chronic illnesses, including obesity, diabetes, insulin and leptin resistance, heart disease, PMS, depression, hypercholesterolemia, chronic fatigue syndrome and fibromyalgia. These common conditions are associated with secondary and tertiary hypothyroidism, abnormal transport of T4 and T3 into the cells, reduced T4 to T3 conversion and thyroid resistance. These abnormalities render the TSH unreliable in patients with such diagnoses. With knowledge of the abnormal thyroid physiology present in such conditions, it becomes clear that the standard method of diagnosis and treatment of hypothyroidism is no longer appropriate. Emerging concepts will be discussed on how to make a diagnosis of tissue hypothyroidism when the TSH is normal.
Topics discussed include:
• Most if not all patients who suffer from depression, obesity, diabetes, insulin resistance, PMS, stress, CFIDS/fibromyalgia, are older or have chronic illness are low thyroid and usually benefit from treatment
• Standard thyroid reference ranges do not apply
• Need more sophisticated blood tests to demonstrate thyroid deficiency
• Standard thyroid medications not a good choice for many people
12:00 PM - 12:45 PM
Advanced Platelet Preparations for Regenerative Orthopedics
Ronald W. Hanson, Jr., M.D.
Fellowship Director, Interventional Orthopedics, Centeno-Schultz Clinic Center for Regenerative Medicine, Broomfield, CO
Lecture Description:
The use of autologous PRP for orthopedics is fragmented and has little supportive literature on the concentration of platelets, WBC and RBC for optimum outcome. Unique data on each of these cells and their effect on mesenchymal stem cells will be presented.
12:45 PM - 1:30 PM
Epigenetics of a Pair of 101-Year-Old Identical Twins Reared Together
L. Stephen Coles, M.D., Ph.D.
Lecturer, Molecular Biology Institute, Department of Chemistry and Biochemistry, UCLA
Co-Founder, Los Angeles Gerontology Research Group
Lecture Description:
A pair of female identical twins were phenotypically identical in their infancy, so much so that their parents couldn’t tell them apart without consultation; both subsequently married and have children, and they have lived in the same general southern California location all their lives. Today at age 101, they are phenotypically quite distinct. Can their methylation profiles be used to explain their significant physical and intellectual differences?
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