Options to Access the Syllabus
- Scroll through the agenda and open Speaker Presentations individually. These PDF files can be viewed or saved.
- The files should open in a new window for your convience. Please allow ample time to download these PDF files as they can be quite large in file size.
- Click here to to download all Speaker Presentations - ZIP File
Agenda April 2015
7:00 AM - 7:45 AM
Look Good, Feel Good, Have Great Sex
Presented by Mitchell J. Ghen, D.O., Ph.D.
Non-CME symposium sponsored by DaVinci Labs
Open to all attendees and includes a complimentary breakfast
8:00 AM - 9:00 AM
Introduction: The Interaction Between Hormones, Nutrients, Toxins, Mind and Body
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Lecture Description:
This lecture will cover the interactions between hormones and nutrients, the role of pH, the role of heavy metals and the function of liver and bowel on hormonal function. It will also cover the role of mental and physical status on hormonal function. This 5-point model is the basis of the cases that will be covered during the day.
9:00 AM - 10:00 AM
Estrogens, Progesterone
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Lecture Description:
This lecture will cover the recent analysis of the Women’s Health Initiative and French Cohort Study. We will cover the data on the different forms of estrogen and progesterone and their different actions. Deficiency symptoms and conditions will be covered. The dosing and route of administration will be discussed. The 5-point model to restoring hormonal function using estrogen and progesterone will be illustrated through case studies in anxiety, insomnia, PMS and PCOS and menopause.
10:00 AM - 10:15 AM
Break
10:15 AM - 12:00 PM
Testosterone and Thyroid
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Lecture Description:
This lecture will cover the recent analysis of the data on testosterone and its effects on cardiovascular system and cancer. We will cover the data on the different forms of testosterone and thyroid and their different actions. Deficiency symptoms and conditions will be covered. The dosing and route of administration will be discussed. The 5-point model to restoring hormonal function using testosterone, thyroid, estrogen and progesterone will be illustrated through case studies in low sex drive, fatigue, weight gain, depression and high cholesterol.
12:00 PM - 1:30 PM
Lunch Break
12:00 PM - 1:00 PM
Telomere Talk: Pearls from 7 years of monitoring patients on TA-65
Presented by Joseph M. Raffaele, M.D.
Non-CME symposium sponsored by T.A. Sciences
Open to all attendees and includes a complimentary lunch
1:30 PM - 2:15 PM
DHEA, Melatonin, Cortisol
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Lecture Description:
This lecture will cover the recent data on DHEA, Melatonin and cortisol. We will cover the data on their different actions. Deficiency symptoms and conditions will be covered. The dosing and route of administration will be discussed. The 5-point model to restoring hormonal function using DHEA, cortisol, melatonin, testosterone, thyroid, estrogen and progesterone will be illustrated through case studies in adrenals and osteoporosis.
2:15 PM - 3:00 PM
Evidence Behind Nutritional Therapies / Superfoods / Plant-Based Nutrition
Margaret Davis
Director of Nutrition, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Lecture Description:
We will discuss the data on the effect of nutrients on hormone function, genes, and organs. This lecture will cover the data on the various plant-based diets and superfoods. Illustrative cases using the 5-point model will demonstrate the application of the various interventions to weight and autoimmune conditions.
2:30 PM - 7:00 PM
Exhibits Open
3:00 PM - 3:45 PM
Break - Visit Exhibits
3:45 PM - 4:30 PM
How to Identify and Address Toxins: Basic Detoxification
Todd Gegerson, D.O.M.
Faculty, Florida College of Integrative Medicine
Acupuncture Physician, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Lecture Description:
We will discuss the data on the effect of toxins on health, hormone function, genes, and organs. This lecture will cover the data on the various methods to identify and remove toxins. Illustrative cases using the 5-point model will demonstrate the application of the various interventions.
4:30 PM - 5:15 PM
Advanced Case Studies: Putting it all Together
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Lecture Description:
Cases will be presented on the topics discussed previously through didactic lecture. Attendees will be encouraged to discuss treatment options and clinical best practices through interactive give and take with faculty.
5:15 PM - 5:30 PM
Q & A
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Todd Gegerson, D.O.M.
Faculty, Florida College of Integrative Medicine
Acupuncture Physician, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Margaret Davis
Director of Nutrition, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Look Good, Feel Good, Have Great Sex
Presented by Mitchell J. Ghen, D.O., Ph.D.
Non-CME symposium sponsored by DaVinci Labs
Open to all attendees and includes a complimentary breakfast
8:00 AM - 9:00 AM
Common Conundrums in the Age Management Care of Women
Julie A. McCallen, M.D.
President, Cenegenics Denver, Denver, CO
Lecture Description:
Cases will cover women who bleed when they shouldn’t, pre and post menopausal. The woman who can’t lose weight, including areas such as, basic hormonal correction, basic nutrition and HIIT, intermittent fasting, more robust hormone based weight loss techniques (can I talk about the use of HCG for this?). The woman who won’t exercise, how to motivate in someone who has never exercised, how to progress, how to encourage to keep the progression going.
9:00 AM - 9:30 AM
Patient with Family History of Heart Disease
Robert D. Willix, Jr., M.D.
CEO, President, Enlightened Living Medicine, Boca Raton, FL
9:30 AM - 10:00 AM
Patients with Nutrient and Nutrition Deficiencies
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
Lecture Description:
A series of complex cases involving patients with nutrient and nutrition deficiencies will be presented as well and clinical treatment options.
10:00 AM - 10:15 AM
Break
10:15 AM - 11:00 AM
Estrogen Dominance and Neuropsychopharmacology
Mark L. Gordon, M.D.
Medical Director, Millennium-TBI & The Millennium Health Centers, Encino, CA; CBS Studios;
USC, Keck School of Medicine, Department of Family Medicine, Los Angeles, CA
Medical Director of Education, Access Medical Laboratories, Jupiter, FL
Member, AMMG Conference Planning Committee
Life Member, AMMG
Lecture Description:
The neuro-psychobehavioral characteristics of any one individual are perceived to be a result of environmental influences. The debate over “nature and nurture” pit our genome against the influences of our environment in that, we are who we are based upon the company we keep or is it the genes we express? Neuroplasticity under the control of genes and regulated by the hormones that bathe our cerebral lobes appears to have both genomic and epigenomic influences on how we respond to a variety of environmental challenges. The neuropsychopharmacology of hormones is an expanding field of understanding showing us that the regulation of reactive emotions from the limbic system is due to changes in the gated-ion channels of neurons. Influencing our intelligence and emotional presence through modulation of receptors such as GABA, NMDA, Sigma-1, and AMPA are a group of hormones referred to as neurosteroids. The most influential neurosteroids that not only regulate receptors, but also the health and regeneration of neurons are Progesterone, Estradiol, Testosterone, Pregnenolone, and their active sulfated forms all manufactured de novo in the brain. It is the absolute loss of these neurosteroids or a precipitated change in their relative balances that can lead to alterations in how we react and how we manage our mental well-being. The real-life case(s) to be presented will help to illustrate the approach to diagnosis and treatment for the loss of well-being.
11:00 AM - 12:00 PM
Complex HRT Cases in Women
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
Prescribing hormones to women is easy 90% of the time. However it is the other 10% that requires skill, experience, insight, and command of the medical literature to appropriately treat complex cases. This lecture will review many complex cases and scenarios that will enable the experienced clinician to handle those difficult cases in women. A literature review will be provided to support why we do what we do in complex cases as thorough understanding of the literature will enable one to understand how we handle complex cases and complications in women. In the end we will review the interventional data supporting early and continuous use of HRT to protect our brain and heart.
12:00 PM - 1:30 PM
Lunch Break
12:00 PM - 1:00 PM
Telomere Talk: Pearls from 7 years of monitoring patients on TA-65
Presented by Joseph M. Raffaele, M.D.
Non-CME symposium sponsored by T.A. Sciences
Open to all attendees and includes a complimentary lunch
1:30 PM - 2:30 PM
Age Management Involving Patients with Prostate Cancer
Kenneth Janson, M.D., FACS
Senior Attending Physician, Northwestern Lake Forest Hospital
Lecture Description:
Young business leader treated surgically for prostate cancer, put on androgen blockade (in my opinion unnecessarily by an overly enthusiastic oncologist), who became impotent, depressed, and gained a great deal of weight. He felt like an old man within months. We evaluated him for consideration of hormone replacement therapy, found him a reasonable candidate (and the issues here are critical for age management physicians to understand when this is safe and when it is not). After therapy he now feels like he has been given his life back. His prostate cancer remains undetectable.
2:30 PM - 7:00 PM
Exhibits Open
2:30 PM - 3:30 PM
Complex HRT Cases in Men
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
Prescribing testosterone to men is easy in 90% of the time. However it is the other 10% that requires skill, experience, insight, and command of the medical literature to appropriately treat complex cases. This lecture will review many complex cases and scenarios that will enable the experienced clinician to handle those difficult cases. A literature review will be provided to support why we do what we do in complex cases.
3:30 PM - 4:15 PM
Break - Visit Exhibits
4:15 PM - 5:30 PM
Use of Fitness, Assessing the Patient and Developing Individualized Treatment Plans
Shahab Mokhtare, M.D.
Partner, Cenegenics, Las Vegas, NV
Lecture Description:
A systematic review of a customized hormonal, nutritional, and training interventional program on measures of functional outcomes in healthy older adults. The importance of assessing the patient, categorizing them and developing an individualized treatment plan will be reviewed. We will further analyze 3 case studies of 2 men, and 1 woman who present with signs and symptoms of aging and hormonal imbalances. Audience interaction is highly encouraged.
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Look Good, Feel Good, Have Great Sex
Presented by Mitchell J. Ghen, D.O., Ph.D.
Non-CME symposium sponsored by DaVinci Labs
Open to all attendees and includes a complimentary breakfast
8:00 AM - 8:30 AM
Stem Cell Basics: What is a Stem Cell? What Are The Possibilities & Different Stem Cell Sources: What Are They Each Good For?
Jamil Bashir, M.D.
Fellow, Interventional Orthopedics, Centeno-Schultz Clinic, Broomfield, CO
Lecture Description:
The application of regenerative strategies to musculoskeletal ailments offers extraordinary promise to transform management of the conditions of numerous patients. The use of cell based therapies and adjunct strategies is under active investigation for injuries and illnesses affecting bones, joints, tendons, and skeletal muscle. Of particular interest to the field is the mesenchymal stem cell, an adult stem cell found in bone marrow and adipose tissue. This cell type can be expanded ex vivo and has the capacity for engraftment and differentiation into mesodermal lineages. This lecture will offer an overview of mesenchymal stem cell biology, the potential sources of these cells and their application in the field of musculoskeletal medicine.
8:30 AM - 9:15 AM
Regenerative Medicine for Immune Dysfunction & Chronic Illnesses
Dipnarine Maharaj, MB.ChB, M.D., FRCP (Edin.), FRCP (Glas.), FRCPath, FACP
Medical Director, The Maharaj Institute of Immune Regenerative Medicine, Boynton Beach, FL
Lecture Description:
Autologous stem cell therapy is an established treatment for immune dysfunction of blood cancers. The lifetime likelihood of an individual in the U.S. needing a hematopoietic stem cell transplant, using either one’s own stem cells or those from a donor is 1 in 200 which is much higher than previously reported estimates (Biology of Blood and Marrow Transplantation, March 2008). In the future it is believed that the need for autologous stem cell therapy will increase as it may offer remedies for strokes and neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases and chronic diseases such as heart disease as well as diabetes. The function of stem cells decrease with age. Healthy adults can undergo a process known as adult stem cell collection where a person’s autologous stem cells are taken from their blood after being mobilized from the bone marrow and the cells can be stored until potentially needed in the future. The process and potential uses
will be discussed. The characteristics of immune dysfunction and its contribution to the development of age-associated chronic diseases in humans will be discussed in this presentation. In addition, immune senescence as it relates to aging and inflammation will be presented.
Stem cell aging contributes to immune dysfunction. An individual’s own stem cells can be safely transplanted without being rejected by the body’s immune system to treat immune dysfunction. Autologous stem cell therapy is an established treatment for immune dysfunction of blood cancers. This presentation will focus on clinical aspects of the use of autologous stem cells for regenerative medicine with emphasis on strategies for optimizing their function by reducing inflammation and improvement of immune dysfunction in patients with chronic illnesses.
9:15 AM - 10:00 AM
The Regulatory Morass: Staying Safe
Andrew S. Ittleman, Esq.
Founder & Partner, Fuerst, Ittleman David & Joseph, Miami, FL
Lecture Description:
Autologous stem cell procedures – medical procedures which use stem cells removed from a patient to treat that same patient’s illnesses or injuries – are subject to an intense level of regulatory scrutiny by the United States Food and Drug Administration (FDA). Although they involve the use of a patient’s own tissue, in most circumstances the FDA perceives these procedures as the manufacturing of a biologic drug, and subjects them to the same approval pathway that it does mass-produced drugs and biological products.
10:00 AM - 10:15 AM
Break
10:15 AM - 11:15 AM
Orthopedic Use of Stem Cells: Registry Experience with 2,000 cases
Christopher Centeno, M.D.
Medical Director, Centeno-Schultz Clinic, Broomfield, CO
Member, AMMG Conference Planning Committee
Lecture Description:
The use of bone marrow stem cells to treat orthopedic conditions dates to the late 1990s for conditions like avascular necrosis and fracture non-union. We report the results of a continuously operated orthopedic stem cells registry that dates back a decade to 2005. The outcomes of common orthopedic conditions such as knee, hip, and shoulder osteoarthritis treated with stem cell injections will be discussed. In addition, the results of other conditions such as rotator cuff tears and ACL tears treated with stem cells will be presented. Finally, large scale safety on 2,300 treated patients will be reviewed.
11:15 AM - 12:00 PM
Cardiac: Using Adipose Stem Cells
Leslie W. Miller, M.D.
Chief Science Officer, Okyanos, Freeport, Grand Bahama
Lecture Description:
Adult stem cell therapy is emerging as a new alternative for patients with severe heart disease including coronary artery disease (CAD) and congestive heart failure (CHF) as well as patients with auto-immune diseases, tissue ischemia, neurological and urological conditions. Dr. Miller will discuss the benefits of adult stem cell therapy for severe heart disease and describe the goal of Cardiac Cell Therapy in treating congestive heart failure and coronary artery disease patients with their own fat-derived stem cells.
12:00 PM - 1:30 PM
Lunch Break
12:00 PM - 1:00 PM
Telomere Talk: Pearls from 7 years of monitoring patients on TA-65
Presented by Joseph M. Raffaele, M.D.
Non-CME symposium sponsored by T.A. Sciences
Open to all attendees and includes a complimentary lunch
1:30 PM - 2:30 PM
Microfat Grafting for Cosmetic and Reconstructive Application: Native Stromal Vascular Fraction (SVF) Graft Enrichment as a Viable Therapeutic Alternative in North America
Alan Yang Wu, M.D., CTBS, FAACS, FACS
Faculty, University of California at Riverside, Stem Cell Research Center
Managing Partner, Surgimed Biosciences, Cathedral City, CA
Lecture Description:
Microfat grafting is a process whereby routine lipoaspirate is processed by simple saline wash and “re-sizing” by passage through progressively smaller filters. This unique method allows for an extremely fine fat graft with a proportionately higher content of SVF macrostructure versus adipose cells. This tremendously versatile graft may be used in aesthetic and/or reconstructive procedures and will be explained in a series of case studies detailing preliminary procedural protocols.
2:30 PM - 7:00 PM
Exhibits Open
2:30 PM - 3:20 PM
Autologous Implant of Stem Cells in Different Diseases: Clinical Experience and Results
Augusto Brazzini, M.D.
Medical Director, Brazzini Institute, Lima, Peru
Professor of Medicine, University of San Martín de Porres, Lima, Peru
Lecture Description:
Adult Autologous Stem Cells, have from the beginning of life, an important and essential role on regenerative activity in all the body, replacing millions of stem cells dying each day. The replacement of adult, autologous stem cells taken from the same patient bone marrow and been injected intra-arterially to the different affected organs, must be considered an innovative physiological process, helping the recovery in different magnitudes to many diseases affecting the human body. Examples and videos will be show.
3:20 PM - 4:00 PM
Break - Visit Exhibits
4:00 PM - 4:50 PM
Treatment of No-Option Chronic Limb Ischemia with a Concentrate of Autologous Bone Marrow Cells
David L. Harshfield, Jr., M.D., M.S.
Director of Interventional Radiology, Medical Center of South Arkansas, El Dorado, AR
Chairman, Institutional Review Board, International Cellular Medicine Society (ICMS)
Lecture Description:
Increase in patients requiring treatment peripheral arterial disease (PAD) and chronic limb ischemia (CLI):
• Aging population results in higher prevalence of disease.
• CLI prevalence increases with Age
• “Epidemic” of Diabetes World-Wide
Patients with no conventional options for surgical or endovascular intervention are termed “No-option CLI” (NO-CLI). Autologous Bone Marrow cell therapy offers extraordinary potential because it exactly mimics and supplements the body’s natural response to injury. Autologous bone marrow cells have shown clinical effect in multiple disease states.
Release of bone marrow cells into circulation is the natural response to repair injured tissue. When this natural response is not strong enough, the response can be enhanced by harvesting these cells, concentrating them and delivering them to the site of injury. Injecting Bone Marrow Cells in proximity to main arteries in ischemic areas has been shown to induce vasculogenesis, thought to be mediated by paracrine effects. Thus, stem cell studies to-date suggest true potential in treatment of CLI:
• BMAC Pivotal study positioned to achieve proof of efficacy
• Study is being conducted in internationally known research centers
• Currently the only Pivotal trial active for this indication
4:50 PM - 5:30 PM
Panel Discussion with Attendee Q & A: Are Fat Stem Cells Processed at the Bedside Drugs? If So, Should They Be?
Christopher Centeno, M.D.
Medical Director, Centeno-Schultz Clinic, Broomfield, CO
Member, AMMG Conference Planning Committee
Alan Yang Wu, M.D., CTBS, FAACS, FACS
Faculty, University of California at Riverside, Stem Cell Research Center
Managing Partner, Surgimed Biosciences, Cathedral City, CA
Andrew S. Ittleman, Esq.
Founder & Partner, Fuerst, Ittleman David & Joseph, Miami, FL
Christopher Centeno, M.D. - Panel Chair
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Physician Training and Certification in Age Management Medicine: Essential Qualifications and Knowledge for the Age Management Medicine Physician
Presented by Jeffrey P. Leake, M.D., Director of Education, AMMEF; Partner Physician, Cenegenics Elite Health
Non-CME symposium sponsored by Age Management Medicine Education Foundation-Cenegenics Elite Health
Open to all attendees and includes a complimentary breakfast
8:00 AM - 8:05 AM
Opening Remarks
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
8:05 AM - 9:00 AM
-- Featured Speaker --
Genome: Clinical Relevancy of Unlocking Life’s Code
Jean Jenkins, Ph.D., RN, FAAN
Clinical Advisor, National Human Genome Research Institute, NIH, Bethesda, MD
Lecture Description:
Discoveries of genomic variation associated with health, disease, and management options, when translated into practice, can make a difference for a patient and his/her family. Get the latest updates relevant for healthcare providers about genomic science and learn how it is changing the nature of healthcare. Gain pragmatic information about the significance of genomics within the context of Age Management Medicine. Review factors to consider when developing interventions to enhance safe, quality precision medicine. Learn about resources such as the Genetics/Genomics Competency Center for Education (G2C2 at http://g-2-c-2.org ) and the Global Genetics and Genomics Community (G3C at http://g-3-c.org ) to enhance your abilities to integrate genomic content into education, policy, and practice.
9:00 AM - 10:00 AM
Resetting DNA
Michael B. Fossel, Ph.D., M.D.
Clinical Professor of Medicine (Retired), Michigan State University
Adjunct Professor of Biomedical Science, Grand Valley State University
Lecture Description:
Aging is an active, dynamic process – rather than a passive accrual of damage – driven by predictable patterns of epigenetic change within cells. The change in gene expression results in decreased DNA repair, protein pool turnover, ATP/ROS ratio, lipid membrane efficacy, and a gamut of changes which define cell senescence. Such intracellular (and intercellular) changes result in predictable tissue and organ dysfunction, including vascular endothelial and microglial cell failure, with secondary clinical pathology, including arteriosclerotic and Alzheimer’s diseases. While clinical interventions can be based on specific genes, the panoply of epigenetic changes are modulated by a loss of relative telomere lengths. Research consistently shows that relengthening of the telomeres results in cellular, tissue, and organismal benefits both in vitro and in vivo. Such data includes human trials of oral telomerase activators and telomere relengthening in animals in vivo, but a more effective intervention may be to use tailored plasmid delivery of active telomerase genes in human subjects. Such trials are now planned.
10:00 AM - 10:45 AM
Break - Visit Exhibits
10:45 AM - 11:30 AM
Physician's Role in Precision Medicine Today
Florence Comite, M.D.
CEO & Founder, Comite Center for Precision Medicine, New York, NY
Member, AMMG Conference Planning Committee
Lecture Description:
Precision Medicine is the natural extension of personalized prevention that allows the physician to reverse or prevent disorders of aging. Cardiovascular disease, diabetes, cancer, degenerative disorders are generally multifactorial, and arise due to numerous triggers, from lifestyle to family history to the microbiome, driven by metabolic and hormonal factors among other variables. Currently, genetic screening has become available as a relevant and essential component to identify risk for the individual. The genetic make-up of individuals can help prospectively to detect potential disorders of aging. However, the genetic blueprint is not absolute, nor is it a predestined outcome. Genes do not dictate destiny, as it has become progressively evident that genetic expression may be variable. Epigenetic factors have an impact on the expression of genetic make-up. Of additional importance is the understanding that DNA switches can act to turn on or off the production of proteins that affect multiple actions that may dictate the advent of Type 2 Diabetes or hair loss, among other multiple and complex actions that occur as individuals age. Recent endocrine studies suggest too that the microbiome, particularly gut organisms, is associated with a spectrum of diseases such as obesity, diabetes, and various cancers. Genetic testing is rapidly being actualized in practice; the clinician
should be comfortable with the interpretation and the significance of diagnostic screening. Patients deserve a solid understanding of the relationship between their genes and disorders of aging. It is vital that the clinician understands how to integrate the various modalities that allow for the precise analysis of factors that may have a deleterious effect on the health span, and is prepared to balance, discuss, and position the possible outcomes in relaying test results. Overall, screening adds great value to our ability to identify underlying influences that might tilt the scales toward various disorders of aging. At the same time, it strengthens our ability to manage and motivate successfully. Further, it allows the clinician to set interventional priorities and weigh the risk-benefit scale of options. Precision Medicine for age management provides more precise and personal guidance with respect to subsequent diagnostic tests and procedures as well as interventions, ranging from lifestyle, addressing sleep, stress, nutrition and exercise, to supplements and medications.
11:30 AM - 12:15 PM
Panel Discussion – Genomics in Age Management Medicine
Florence Comite, M.D.
CEO & Founder, Comite Center for Precision Medicine, New York, NY
Member, AMMG Conference Planning Committee
Jean Jenkins, Ph.D., RN, FAAN
Clinical Advisor, National Human Genome Research Institute, NIH, Bethesda, MD
Michael B. Fossel, Ph.D., M.D.
Clinical Professor of Medicine (Retired), Michigan State University
Adjunct Professor of Biomedical Science, Grand Valley State University
Florence Comite, M.D. - Panel Chair
12:15 PM - 1:30 PM
Lunch Break - Visit Exhibits
12:15 PM - 1:15 PM
Sub-cutaneous Hormone Pellet Therapy: Alternative Medicine or an Alternative to Bad Medicine
Presented by Gary S. Donovitz, M.D., FACOG, FRSM
Non-CME symposium sponsored by BioTE Medical
Open to all attendees and includes a complimentary lunch
1:30 PM - 2:20 PM
Role of Genetic Guided Nutritional Supplementation Therapy in Age Management Medicine
Ovidiu N. Penes, Ph.D., M.D.
Clinician & Age Management Medicine Specialist, Bucharest, Romania
Faculty, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
NOTE: This presentation is not available online.
Lecture Description:
When conducting an age management therapy, the commercially available genetic tests can offer valuable information to the clinician, which aids in a proper guidance. By analyzing genetic polymorphisms linked to detoxification capacity, predisposition to oxidative stress and other major aspects of human health such as hormone management and individual genetic predispositions to diseases, the clinician can choose the most effective nutritional supplements in order to particularize even further the age management therapy and help the patient achieve the maximum potential. The course is practical and reveals ways to adapt the patient nutritional supplementation therapy based on genetic polymorphisms.
2:20 PM - 3:00 PM
The Discovery of Inflammasome-Activation and Signal Transduction of Non-Specific Cellular Responses in Food Intolerance
Sanjay Kapur, Ph.D., MBA
CEO, AYUMETRIX, Portland, OR
Lecture Description:
The chemical composition of foods, by virtue of its mere ingestion, can activate various receptors, such as PPAR receptors and STAMP 2 (six trans-membrane protein of prostate – 2) inducing either inflammatory or anti-inflammatory pathways in cells. After DAMP release and their binding to corresponding pattern recognition receptors (such as TLR4) it induces the assembly of cytosolic proteins: The inflammasome. Individual phenotypes can also react to foods in non-classically allergic, idiosyncratic fashion, through the innate immune system. Such activation leads to the generation of toxic mediators and free radicals. A key role in these inflammatory signaling cascades plays the inflammasome. Various current studies have shown that it is involved in the following processes e.g. the antimicrobial defense of the body, development and outbreak of the metabolic syndrome, regulation of insulin, weakening of the ß-cell function in the insulin producing islet cells of the pancreas (promotion of type 2 diabetes), vascular plaque formation, sterile inflammation of the liver and other organs, immune response of the mucosa, especially of the intestinal mucosa, also altering the critical ecology of the gut microflora. The effects of the modern diet, the mechanisms underlying the inflammatory innate pathways so activated by dietary and lifestyle factors, the extant methods of examining food intolerance, as distinct from food allergy, will be also discussed in this lecture.
3:00 PM - 3:30 PM
Break - Visit Exhibits
3:30 PM - 4:20 PM
Multi Systemic Implications of the Microflora Effect on the Body
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
Lecture Description:
Probiotics also known as the “good bacteria” make up about 4 lbs of body weight. The human Micro-Biota out number our genes 10:1. Probiotics are involved in more than Immune and digestive function in the human body. There is data to suggest that the gut microbes play a role in vitamin production, mood disorders, memory and even blood sugar regulation. There is also new to data suggesting that changing the pH our stomach may alter out immune function and make us more susceptible to infection. We will look at the data and show some startling effects that the human micro-biota play in our overall health.
4:20 PM - 5:30 PM
Beyond the Basics: Functional Medicine Approach to Gastrointestinal and Immune Dysfunction
Jill C. Carnahan, M.D., ABFM, ABIHM, IFMCP
Medical Director & Founder, Flatiron Functional Medicine, Boulder, CO
Certified Practitioner, Institute of Functional Medicine
Lecture Description:
The rapid rise of gastrointestinal and immune dysfunction in our patient populations presents an increasing clinical dilemma. This CME program will provide a cutting edge functional medicine approach to diagnose and treat common gastrointestinal and immune dysfunction. Dr. Jill Carnahan will provide advanced diagnostic and treatment protocols and innovative approaches to improve outcomes for your most difficult-to-treat patients with gastrointestinal and immune dysfunction.
7:00 AM - 7:45 AM
Working Within the Regulations for Growth Hormone - Options
Presented by Mark Gordon, M.D.
Non-CME symposium sponsored by University Specialty Drugs
Open to all attendees and includes a complimentary breakfast
8:00 AM - 8:50 AM
Heavy Metals as Endocrine Disruptors
Edwin N. Lee, M.D., FACE
Assistant Professor of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL
Founder, Institute for Hormonal Balance
Member, AMMG Conference Planning Committee
Lecture Description:
Heavy metals like mercury, lead, arsenic and cadmium are silent killers in our current society. Heavy metals can disrupt the endocrine system and have been linked to metabolic syndrome, obesity, hypothyroidism, autoimmune thyroid disease, low testosterone, estrogen dominance and diabetes. The role of heavy metals as environmental toxins being the root cause of endocrine diseases is underappreciated in clinical practice. The controversy of diagnosis of heavy metals and treatment will be reviewed.
8:50 AM - 9:40 AM
Toxicants and Clinical Practice: An Underappreciated ‘Root Cause’ for Chronic Disease
Kara Fitzgerald, N.D.
Adjunct Faculty, University of Bridgeport, CT
Clinician & Researcher, Family Institute for Therapeutic Discovery, Sandy Hook Clinic, Newtown, CT
Faculty, Institute for Functional Medicine
Lecture Description:
Exposure to environmental toxicants is now recognized to be a significant factor in the development of complex, chronic disease. Toxicants like polychlorinated biphenyls (PCB), chlorinated pesticides, and volatile solvents have been linked to obesity, metabolic syndrome, cancer, autism, Parkinson disease, and heart disease. Epidemiologic data such as that reported via NHANES suggest that environmental toxicants impact the general public at large, not just those with work related exposure – and this impact is especially pronounced in the young and elderly. Exposure to environmental chemicals may be an additional risk factor that, if prevented, could facilitate a reduction in disease incidence and in the overall associated health burden. Given that, clinicians who understand how best to assess exposure and apply effective treatment strategies are more likely to address the impact of toxins before the onset of chronic disease. In this presentation, Dr. Kara Fitzgerald will use case studies to evaluate the impact of both environmental toxins and effects of targeted treatment strategies. Identifying environmental toxin load can aid in the full understanding of how environmental toxins can impact many areas of function – and ultimately, whole body – health in clinical practice. By exploring the impact of environmental toxin load, we will ultimately discuss how such strategies can support personalized patient care throughout the lifespan.
9:40 AM - 10:20 AM
Break - Visit Exhibits
10:20 AM - 11:15 AM
Two New Endocrine Organs
Gary Donovitz, M.D., FACOG, FRSM
Founder and CEO, BioTE Medical, Irving, TX
Founder and President, Institute for Hormonal Balance
Lecture Description:
We are used to energy metabolism and reproduction being attributed to the Hypothalamic Pituitary axis. There are two new endocrine organs bone and fat. They may be more relevant in regards to their benefit to energy metabolism and reproduction. In addition, they are significant in bone mass accrual and appetite. The most important hormones from these new endocrine organs are leptin, adiponectin, and osteocalcin. There is a fascinating interplay between these hormones and those produced by the H.P.A. Leptin has effects on appetite. It has a neuro-protective role in reducing Alzheimer’s disease. Leptin also has effects on reproduction independent of estrogen and progesterone. Unfortunately, at high levels it has pro-inflammatory activities. Osteocalcin effects energy metabolism, total fat mass, and insulin secretion. It has an overall effect on all-cause mortality. Osteocalcin acts co-incidentally with the H.P.A. increase testosterone. As osteocalcin travels to fat cells, the third hormone in this new endocrine system, adiponectin, is released. Adiponectin like testosterone and growth hormone increase insulin sensitivity. It also acts on the osteoblast to increase new bone formation. The Hypothalamic- Pituitary- Gonadal Axis is NOT the only important hormone axis in the body. The Adipose-Bone-Pancreatic Axis may be the more important axis for: energy metabolism, appetite, bone growth, heart protection, brain protection, prevention of diabetes, and the prevention of metabolic
syndrome.
11:15 AM - 12:00 PM
Adrenal Fatigue in Perimenopause and Menopause
James L. Wilson, N.D., D.C., Ph.D.
Founder and Research Director, Health Science Research Foundation
President and Chief Formulator, ICA Health, Tucson, AZ
Lecture Description:
Perimenopause and menopause are often challenging health issues for healthcare practitioners and their patients. Mainstream medicine has recently upped its interest in women's hormone health, shown by assigning ICD codes to both and recommending large amounts of various hormones - often synthetic and not bio-identical- which has created it's own additional set of new signs and symptoms. Physicians have come to regard both conditions as something to treat, rather than as indicators of a system out of balance, that needs balancing. The purpose of this presentation is to give the attendees an alternative to the present way of thinking - this approach details a comprehensive analysis and treatment protocol, the coal of which is to re-establish hormonal balance, and provides easily implemented options for the successful treatment of perimenopause and menopause based on 35 years of my clinical experience.
12:00 PM - 1:15 PM
Lunch Break - Visit Exhibits
1:15 PM - 2:05 PM
Estrogen Metabolism and Breast Cancer Risk
David T. Zava, Ph.D.
President & CEO, ZRT Laboratory, Beaverton, OR
Lecture Description:
To review the medical literature and different methods used to assess the association of estrogen metabolism and breast cancer risk. Even though mortality caused by diseases of aging (e.g. heart disease, diabetes, osteoporosis) is much greater than that of breast cancer, women’s greatest fear is the diagnosis of breast cancer. Research and clinical studies clearly show the benefit of lifestyle intervention in preventing primary breast cancer and secondary recurrence. At the cellular level the types of estrogen metabolites that form, more so than the level or type of estrogen present, predicts the extent of DNA damage and risk for developing breast cancer. Methods to monitor the types of estrogen metabolites, and therefore breast cancer risk, are now available through testing in urine.
2:05 PM - 3:00 PM
Thyroid vs. The Thyroid System
Shanhong Lu, M.D., Ph.D.
Owner, Mt. Shasta Integrative Medicine, Mt. Shasta, CA
Owner, Redding Integrative Medicine, Redding, CA
Executive Director, Orenda International, Tempe, AZ
Lecture Description:
Lecture will define hypothyroidism and provide the rationale that hypothyroidism is a modern silent epidemic. One of the key issues will be what labs to order and how to understand these labs when many times they show normal but the patient is still hypothyroid. Dr. Lu will provide evidence of how environmental toxins, stress and missing key nutrients are the root causes of thyroid system dysfunction and provide attendees with effective, evidence based stepwise approaches to achieve sustainable healthy thyroid functions.
3:00 PM - 3:30 PM
Break - Visit Exhibits
(Exhibits Close 4:00 PM)
3:30 PM - 4:20 PM
Peptides: An Emerging Revolutionary Therapeutic Approach
Robin J. Willcourt, M.D.
Medical Director, EpigenX Integrated Medicine
Private Practice, Anti-Aging Medicine, Weight Loss, Sports Nutrition and Hormone Replacement Therapies, Melbourne, Australia
Lecture Description:
A group of chemicals, based on naturally occurring peptide messengers and hormones involved in normal human physiological processes is emerging. The effects of peptides vary from treating sexual dysfunction to inducing a ‘suntan.’ Others affect the immune system enhancing its ability to modify the effects of autoimmune diseases including glomerular diseases and even cartilage regeneration. Perhaps the most extraordinary peptide to emerge is AOD 9604, which has anti-inflammatory properties which lead to an immediate reduction in pain wherever it is injected or applied topically. In early clinical studies it has been found to heal and relieve burn pain with more efficiency than any other known treatment. Follistatin is the only substance known to induce muscle satellite cells to become new muscle cells, i.e., hyperplasia rather than hypertrophy. Thymosin beta-4 affects immune responses and is integral to formation of growth of normal tissue when damage has occurred rather than the chaotic formation of scar tissue that normally happens. These two peptides affect activin and actin, both
of which are involved in tissue repair but which often produce disordered growth in the new tissue. Cjc-1295 and ipamorelin boost the natural production of Growth Hormone (GH). This is an alternative to the expensive r-hGH mostly commonly used for boosting IGF-1 and has the advantage of inducing all five of the hGH isoforms rather just the one that is found in the synthetic form. These peptides operate on the normal feedback loop so that overdosing is limited. GH boosting is being studied as a pre-surgery adjunct to see if healing and recovery times are shortened. Melanotan 2 stimulates melanocyte stimulating hormone. It has potential as an appetite suppressant and from one of its other side effects it has been used to treat decreased libido. From this peptide, Bremelanotide has been developed and is currently in trials for the treatment of Female Sexual Dysfunction. It is effective in treating erectile dysfunction.
4:20 PM - 5:30 PM
Biochemical Roles of Estrogen Receptors Alpha and Beta in Assessing the Safety of Bioidentical Hormone Replacement Therapy
Naina Sachdev, M.D.
Medical Director, NainaMD Advanced Aesthetics and Integrative Medical Center, Beverly Hills, CA
Lecture Description:
This lecture strives to give the practitioner biochemical knowledge on the difference between alpha and beta estrogen receptors. It is with this scientific understanding that will help the practitioner understand how much safer it is to administer bioidentical hormone replacement therapy. Importance of receptor induction and localization of estrogen receptors will be discussed with evidence of why estrial is safer option in BHRT. Finally, some of the nutrigenomic nutrients affecting estrogen alpha and beta activity will be discussed.
7:00 AM - 7:45 AM
Low Dose Naltrexone: An alternative and safe approach for immune dysfunction
and the chronic inflammatory state
Presented by Jill P. Smith, M.D.
Non-CME symposium sponsored by Immune Therapeutics
Open to all attendees and includes a complimentary breakfast
8:00 AM - 9:00 AM
The Art of Person-Centric Medicine: Keeping the Patient at the Center of Your Professional Universe
Gregory W. Petersburg, D.O.
Owner & Medical Director, Renascence, Tucson, AZ
Owner, Living Younger Lifestyle & Proactive Aging Medicine System
Lecture Description:
Over the last 14 years the Institute of Medicine (IOM) has released numerous reports that address quality and safety in health care systems, health professions and nursing. A core component of quality care is patient-centered care. Patient-centered care is care based on a partnership between the patient, their families, and the health care provider that is focused on the patient's values, preferences, and needs. Effective communication between the patient and health professionals is an essential requirement for patient-centered care. Furthermore, the IOM requires health professions education to include core competencies in patient-centered care in order to meet the needs of patients and the changing health care system. Randomized studies correlate physicians engaged in patient-centered care with fewer hospitalizations, fewer diagnostic tests and specialty referrals, and lower overall medical costs, while several studies document higher utilization rates for diagnostic tests, hospitalizations, prescriptions, and referrals among doctors who are poor communicators. Moreover, treatment by empathic and communicative physicians has been correlated with improved outcomes such as better control of diabetes. No new expensive oral antiglycemics or new sophisticated monitoring devices are required for this improvement; rather, it appears that when given a better relationship with their care givers, patients responded with better compliance, and, hence, better diabetes control. This
timely presentation intends to move the practitioner from “What’s the matter” with our patients to “what matters” to our patients. The session provides the practitioner with practical, yet highly effective, strategies to get better at patient-centered medicine. The expected benefits to the practitioner are higher CG-CAHPS scores, better clinical outcomes, improved reimbursement, greater professional satisfaction, less burnout and fewer lawsuits.
9:00 AM - 10:00 AM
Restoring Optimal Energy and Stamina Using Hormones, Nutrients, Detoxification and Mind/Body Interventions
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Lecture Description:
Complaints of low energy and stamina are the number one symptoms currently reported by our patients in all age groups. Energy drinks are the number one growing drink in the U.S. Complaints of fatigue never stand alone. Starting with this symptom, we also see the rest of the consequences of general inflammation and aging, which we are seeing at a younger age. Is it stress alone? Is it poor nutrition? Is it low hormone production? Is it the adrenals or the thyroid? Or are there a number of underlying causes in combination? With all the options available, when do you use cortisol? When do you add thyroid? Do nutritional IV's have a role? How does one address the sub-conscious factors? When should we address toxins such as Lyme's and EBV? Come to this lecture to learn an evidence-based restorative approach that has been used in thousands of patients to recover energy, stamina and vitality. This lecture will be centered around illustrative case presentations.
10:00 AM - 10:15 AM
Break
10:15 AM - 11:00 AM
What All Clinicians Should Know About HRT For Men But Don’t: A Literature Review of the Controversies in Treating Men for Polycythemia and with Aromatase Inhibitors
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
There is no other therapy that physicians can offer that has the impact and importance in improving how we feel and function as does hormone replacement, and this applies to both men and women. There is no other therapy that has the long term studies and literature support for improving longevity and decreasing the diseases of aging which can lead to deterioration in our function and ultimate demise. However it has become customary to use aromatase inhibitors to block formation of estrogen and it has become customary to phlebotimize men with polycythemia, both of which are side effects of testosterone therapy. Even though these treatments are standard treatment of men, neither is supported by the medical literature and both have significant adverse consequences on men’s health. In spite of the widespread use of these treatments, both are incorrect and inappropriate extrapolations or misunderstanding of medical literature. The purpose of this lecture is to present the lack of need to block estrogen in men and the inappropriate phlebotomy of men with erythrocytosis. Using the medical literature, we will come to understand the importance of optimizing estrogen instead of blocking it. The medical literature, as it pertains to the harm of blocking estrogen and importance of optimizing E2, will be emphasized. The safety and importance of erythrocytosis and the difference between erythrocytosis and thrombotic-producing polycythemia will be reviewed. The importance of following
evidence based standards, and not public opinion, will be explained and demonstrated.
11:00 AM - 12:00 PM
Effects of Hormones on Pathogenesis and Management of Dermatologic Conditions, with a Focus on Acne
Trevor Cates, N.D.
Spa Doctor, St. Regis Remède Spa, Park City, UT
Naturopathic Physician & Independent Wellness Consultant, Park City, UT
Lecture Description:
Our patients’ skin is a key indicator of imbalances occurring within the endocrine system. For example, we often see dry skin in hypothyroidism, skin tags in insulin- resistance, and acne with polycystic ovary syndrome. Patients have sensitivity about their skin appearance, and because it is an indicator of other imbalances within the body, it is important to address. In this presentation, I will focus on the effects of hormones on pathogenesis and management of acne and how a holistic approach can address the underlying causes of acne and other associated health disorders. Acne affects more than 40 million people, and more than half of these are women older than 25 years of age. Menarche, perimenopause and pregnancy are some of the more common times acne appears in a woman’s life, as well as with health conditions including PCOS. Androgens such as dihydrotestosterone and testosterone, dehydroepiandrosterone sulfate, estrogens, growth
hormone, and insulin-like growth factors may all contribute to the development of acne. Certain medications including anabolic steroids, oral contraceptives, some anti-seizure medications, isoniazid and rifampin, lithium and iodine-containing medications can cause acne. Exposure to high levels of environmental chemicals such as chlorine compounds, particularly chlorinated dioxins, may cause severe, long-lasting acne, known as chloracne. Conventional treatments for acne often fail or come with unwanted side effects. In this presentation, I will cover some of the research that has helped to show the important role hormones play in the pathogenesis of acne. I will also cover holistic treatments that effectively address the underlying problem and resolve endocrine imbalances and acne.
12:00 PM - 1:30 PM
Standard Pharmacological Therapies: Novel Applications for Age Management Medicine
Luis Martinez, M.D., MPH
President, Regenera Global, Ponce, Puerto Rico
President, XanoGene Clinic, San Juan, Puerto Rico
Lecture Description:
This lecture will discuss and identify standard pharmacological therapies that can and are being integrated into Age Management Medicine patient treatment plans. We will define the specific mechanisms of action through which multiple pharmacotherapies can positively impact the aging process and identify patient populations that could benefit from standard pharmacotherapy applied for Age Management Medicine purposes.
|
 |
|