Options to Access the Syllabus
- Scroll through the agenda and open Speaker Presentations individually. These PDF files can be viewed or saved.
- The files should open in a new window for your convenience. Please allow ample time to download these PDF files as they can be quite large in file size.
- Click here to download all Speaker Presentations (400 MB .zip file)
Download the Conference Guidebook (PDF)
Agenda November 2015
7:00 AM - 7:45 AM
Preview of the AMMG Spring 2016 Track: Understanding Your Genome - Integrating Genomics Into Your Practice
Includes an Opportunity for Attendees to Obtain, GenoSequence and Interpret the Results of their Own Genetic Profile
Florence Comite, M.D. - Introduction
Erica Ramos, MS, LCGC, Sr. Staff Genetic Counselor, UYG Program, Illumina
Open to all attendees and includes a complimentary breakfast
Non-CME symposium sponsored by The Age Management Medicine Group (AMMG)
8:00 AM - 8:45 AM
Adrenal Fatigue, DHEA, DHEAS and Hormone Replacement Therapy
James L. Wilson, N.D., D.C., Ph.D.
Founder and Research Director, Health Science Research Foundation
President and Chief Formulator, ICA Health, Tucson, AZ
Lecture Description:
Hormone replacement therapy (HRT) is being practiced by a growing number of health practitioners. Steroid hormones are powerful biochemicals that not only directly influence the aging process but also help profoundly determine the patient’s quality of life experience. Unfortunately, many people enter into perimenopause and andropause in a stressed state that makes the transition more difficult. What is even more unfortunate is that few practicing physicians understand the interrelationships, overlapping effects or overdose symptoms of hormones thoroughly enough, and especially that they have not been educated about the pivotal role of the adrenal glands in this time of transition. Because the adrenals are the major or strong ancillary supplier of the hormones most often replaced in HRT, it is imperative that every physician doing HRT understands how profoundly adrenal function and proper adrenal support, when needed, affects the outcome of HRT. This presentation will review the relationship between the adrenals and other endocrine glands involved in the process of perimenopause, menopause and andropause, as well as some of the common interactions of the hormones most prescribed in HRT in the aging adult – estrogen, progesterone and testosterone. It will briefly introduce adrenal fatigue and its role in this transition, including the role of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS), two adrenal hormones.
8:45 AM - 9:45 AM
The Nuts and Bolts of Testosterone Replacement Therapy
Rob Kominiarek, D.O., FACOFP
President and Medical Director, ReNue Health, Springboro, OH
Assistant Clinical Professor, Ohio University College of Osteopathic Medicine
Lecture Description:
Testosterone replacement therapy has grown rapidly over the past several years. In 2013 there were approximately 7.5 million prescriptions written for testosterone products and in 2014 it is estimated that 12.5 million prescriptions were written. But, does every man with low levels of testosterone need testosterone replacement therapy? Does every man respond the same to testosterone replacement therapy? It is well known that as we age hormone production and nutrient status decline each decade and daily our bodies are assaulted by various environmental toxins, pollutants, chemicals, and stress that further impacts our hormones. However, it is possible to naturally regain appropriate levels of free testosterone in individuals with an intact H-P-G axis and functional liver. This lecture will provide attendees an overview of the steps necessary to take to help the individual produce testosterone naturally, detoxify the liver, and remove negative environmental influences. Attendees will further learn the difference between screening laboratory for low testosterone and laboratories necessary for safe initiation of testosterone replacement therapy; food sensitivity testing; nutrient level testing; methylation polymorphisms that affect dosing; complex, interesting, and confusing cases; and cases of restoring the free testosterone level through natural methods.
10:00 AM - 11:00 AM
Everything That You Should Know About Treating Insulin Resistance With HRT But Don't
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
A recent Cardio-Metabolic Summit was held with the emphasis on treating metabolic disorders in order to affect cardiovascular outcomes. The lectures presented were no different than the same typical diet, exercise, life style change, and diabetic and cholesterol drugs. Unfortunately there was no mention of the benefits of hormone replacement, which in my opinion, could avoid all the other drugs, side effects, problems and complications. There is a plethora of data that supports the metabolic effects of estrogen, testosterone, DHEA, thyroid and HGH that could benefit patients but seems to be ignored or rejected by medical societies. This lecture will review the medical literature which demonstrates the cardio-metabolic benefits of hormone optimization as it pertains to the treatment of insulin resistance, decrease in visceral fat, and weight loss.
11:00 AM - 12:00 PM
Nuts and Bolts in Thyroid Management
Edwin N. Lee, M.D., FACE
Assistant Professor of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL
Founder, Institute for Hormonal Balance
Member, AMMG Conference Planning Committee
Lecture Description:
Over 30 million Americans have underactive thyroid and over 10 million are undiagnosed. The management of treating underactive thyroid and ignoring TSH is a controversial topic. The dangers of suppressing TSH and also TRH will be reviewed as well as a review of thyroid hormone synthesis. The benefits of using T3 and monitoring reverse T3 will be covered as well as the controversy of the usage of iodine in treating hypothyroidism. The breakdown of T4 into Free T3 and Reverse T3 depends on the deiodination system and the subject of genetic mutation of the deiodination gene will also be reviewed.
12:00 PM - 1:30 PM
Lunch Break
12:00 PM - 1:00 PM
Telomere Biology Workshop: Pearls from 7 Years of Monitoring Patients on TA-65®
Presented by Joseph M. Raffaele, M.D.
Open to all attendees and includes a complimentary lunch
Non-CME symposium sponsored by T.A. Sciences
1:30 PM - 2:30 PM
The Ins and Outs of Estrogen in Women
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Lecture Description:
In this presentation, learn about the data that supports the use of estrogen for protection from disease of the brain, bone, and heart. Learn about the symptoms and conditions that indicate low estrogen. Does estrogen cause cancer or protect from cancer? Is it appropriate to use estrogen without progesterone? Should you use oral or transdermal estrogen? What are the forms and routes (oral, transdermal, vaginal, pellets) and doses? All principles will be demonstrated through cases.
2:00 PM - 7:00 PM
Exhibits Open
2:30 PM - 3:15 PM
Break - Visit Exhibits
3:15 PM - 4:00 PM
Brain Effects of Progesterone (and its Metabolites Pregnenolone and Allopregnanolone) and Melatonin
Angeli Maun Akey, M.D., FACP
Medical Director & Owner, Ageless Medical Solutions, Gainesville, FL
Medical Director & Owner, North Florida Integrative Medicine, Gainesville, FL
Lecture Description:
The neuroprotective effects of progesterone have been explored in the trauma literature with the PEOTECT trial and the SYNAPSE trial using intravenous progesterone after traumatic brain injury from motor vehicle accidents after phase 2 clinical trials were positive for better neurological outcomes. The results of the SYNAPSE trial are currently pending. Also there have been studies of progesterone in acute cerebrovascular events with positive outcomes. This lecture will explore the brain effects of progesterone and its metabolites pregnenolone and allopregnanolone as well as probable mechanisms of observed mood stabilization in the perimenopausal and menopausal woman. This translates to rational use for progesterone in helping deep, quality sleep in the perimenopausal transition and menopause. The brain and sleep effects of melatonin will also be explored.
4:00 PM - 4:45 PM
Update on Growth Hormone 2015
Mark L. Gordon, M.D.
Medical Director, Millennium-TBI & The Millennium Health Centers, Encino, CA; CBS Studios;
USC, Keck School of Medicine, Department of Family Medicine, Los Angeles, CA
Medical Director of Education, Access Medical Laboratories, Jupiter, FL
Member, AMMG Conference Planning Committee
Life Member, AMMG
Lecture Description:
The fetal body’s production of growth factors (GH, IGF-1, IGF-II) allows for the development and growth of each organ system from brain to bones. As our body takes on a more adult form the production of Growth Hormone diminishes over the years. Once thought to be the sole benefactor to linear growth (gigantism) has been found to participate in the optimal production and functioning of all hormones. Growth hormone works with vitamin D in the kidneys to independently produce 25 (OH) Vitamin D, GH provides a stimulus for the conversion of T4 to T3, GH working with Testosterone enhancing memory at the level of the hippocampus, GH and Testosterone as well as Estradiol improve upon endothelial functioning and repair of the basilar membrane, IGF-1 produced by GH signaling improves protein synthesis by up regulating the 40-70S unit of the Ribosomes, rebuilds the tau protein based microtubules destroyed by Amyloid-Beta in Alzheimer’s disease, lowers homocysteine, cytokines and interleukins thereby reducing inflammation. Knowing how best to detect alterations in growth hormone and its by-products will allow for comprehensive preventative programs of wellness to be developed. Understanding the legal requirements for justifiable prescribing of growth hormone will allow the physicians to provide uncompromising services to and for the patient.
4:45 PM - 5:30 PM
Hormone Case Studies with Q & A
Edwin N. Lee, M.D., FACE
Assistant Professor of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL
Founder, Institute for Hormonal Balance
Member, AMMG Conference Planning Committee
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Rob Kominiarek, D.O., FACOFP
President and Medical Director, ReNue Health, Springboro, OH
Assistant Clinical Professor, Ohio University College of Osteopathic Medicine
Lecture Description:
Faculty will present clinical cases involving hormone replacement through an interactive discussion with audience attendees
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Preview of the AMMG Spring 2016 Track: Understand Your Genome - Integrating Genomics into Your Practice
Includes an Opportunity for Attendees to Obtain, GenoSequence and Interpret the Results of their Own Genetic Profile
Florence Comite, M.D. - Introduction
Erica Ramos, MS, LCGC, Sr. Staff Genetic Counselor, UYG Program, Illumina
Open to all attendees and includes a complimentary breakfast
Non-CME symposium sponsored by The Age Management Medicine Group (AMMG)
Session Held in Tower Ballroom just prior to Track #1
8:00 AM - 9:00 AM
Complex Hormone Replacement Cases in Men
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
Prescribing testosterone to men is easy 90% of the time. However, it is the other 10% that requires skill, experience, insight, and command of the medical literature to appropriately treat complex cases. This lecture will review many complex cases and scenarios that will enable the experienced clinician to handle those difficult cases. A literature review will be provided to support why we do what we do in complex cases.
9:00 AM - 9:45 AM
Advanced Case Studies - Cardiovascular Disease, Genomics and HRT
George C. Shapiro, M.D., FACC
Adjunct Assistant Professor Clinical Medicine, New York Medical College, Valhalla, NY
Founding Partner, Cenegenics, New York City
Member, AMMG Conference Planning Committee
Lecture Description:
Advanced case studies to be discussed will involve patients who are interested in beginning HRT but have an array of cardiac conditions such as coronary artery disease, coronary artery stents, CABG surgery, hypertension, atrial fibrillation, cardiomyopathy and genetic mutations of the following genes: SLCOB1, PCSK9, MYH7, MYBPC3, KCNQ1, KCNH2, SCN5A, VKORC1 and CYP2C9.
10:00 AM - 10:40 AM
Prostate Revolumization and PSA Rise in a Patient at Risk for Prostate Cancer and Failure of Clomiphene to Increase Libido Resolved with HCG
Jeffrey P. Leake, M.D., ISSA-CPT
Senior Institute Physician, Course Director for Physician Training and Certification in Age Management Medicine, Cenegenics Medical Institute, Las Vegas, NV
Lecture Description:
Case study will explain the effects of testosterone and PSA in men of varying ages and explain the use of clomiphene citrate in the treatment of secondary hypogonadism.
10:40 AM - 11:30 AM
The Clinical Application of Precision Medicine: Case Study Presentations of the Typical Patient, the Deceptive Patient, and the Complex Patient
Steven M. Villagomez, M.Ed.
Exercise Physiologist, ComiteMD Center for Precision Medicine, New York, NY
Clinical Instructor & Assistant Professor, Exercise Physiology Graduate Program, Long Island University
Nicole M. McDermott, RPA-C
Physician Assistant, ComiteMD Center for Precision Medicine, New York, NY
Lecture Description:
No two people are alike, so why are we still using the “one size fits all” approach in medicine? The National Institutes of Health (NIH) defines Precision Medicine as an emerging field for disease treatment and prevention that takes into account specific variability in genes, environment, and lifestyle for each person. Comprehensive evaluation of metabolic, hormonal, genetic, nutrient and lifestyle factors allows us to determine a patient’s current and future health. Precision Medicine enables a clinician to partner with an individual to yield a deeper, more 'precise' understanding of the individual's health destiny, with the goal of optimal health and longevity. Each individual must be assessed as a “total” person who is more than the sum of his or her parts.
11:30 AM - 12:00 PM
Chronic Low Grade CRP Elevation Leading to Diagnosis of Chronic Lyme Disease and Use of Injectable Depo Testosterone in Women When Topical T Fails to Provide Clinical Benefit
Bhavesh K. Patel, M.D.
Founder and CEO, Cenegenics, Chicago, IL
Lecture Description:
Two cases presented; the first will explore diagnostic efforts for chronic elevations in CRP that don’t seem to go down after intervention; and using injectable Depo Testosterone in women.
12:00 PM - 1:30 PM
Lunch Break
12:00 PM - 1:00 PM
Telomere Biology Workshop: Pearls from 7 Years of Monitoring Patients on TA-65®
Presented by Joseph M. Raffaele, M.D.
Open to all attendees and includes a complimentary lunch
Non-CME symposium sponsored by T.A. Sciences
1:30 PM - 2:15 PM
Hormone Hold-Ups: How to Handle Common Issues Associated with Hormone Use
G. DeAn Strobel, M.D., FACOG
Founder and President, G. DeAn Strobel, MD, PA, Sherman, TX
Founder and President, Allure Laser & Medical Spa, Sherman, TX
Teaching Faculty, Medical Advisory Board, and Mentor, BioTE Medical, Irving, TX
Lecture Description:
When patients follow a doctor’s instructions, many of the patients will do well, feel better and not have any trouble at all…but what does one do when the patient has side effects or doesn’t respond as expected? This lecture will focus on how to address some of the most commonly seen side effects or problems associated with hormone replacement therapy such as postmenopausal bleeding, acne, edema and more.
2:00 PM - 7:00 PM
Exhibits Open
2:15 PM - 3:00 PM
Effectively Training and Motivating Older Patients When They Are Not Serious About Physical Fitness
Mary L. Corry, RN, BSN
Medical Education Specialist, Worldlink Medical
Member, AMMG Certification Committee
Member, AMMG Conference Planning Committee
Lecture Description:
The senior population suffers from chronic diseases such as coronary artery disease, hypertension, diabetes and hypercholesterolemia. One-third of seniors will suffer a hip fracture or fall due to sarcopenia and chronic progression of osteoporosis. Also, depression in the older patients is associated with increased mortality and increased functional limitations (US Census Bureau, 2010). Healthcare professionals understand that management of chronic disease in seniors and prevention of falls should include a regular physical fitness program, however, only 16.1% of adults 65 years of age reported doing strength training at least two times per week (Preventive Medicine 2014). In order for healthcare professionals to be able to help seniors increase their physical activity, they need to understand their client’s physical limitations and emotional challenges. During this presentation, three case studies of women that have trained in the Enhanced Fitness and Silver Sneaker exercise programs will be discussed with each client experiencing different physical limitations and psychological issues. Both exercise programs have balance exercises and safety cues to help prevent future falls and injury and both programs meet the current recommendations of the American Academy of Sports Medicine and The American Heart Association’s guidelines for activity of clients who are 65 years of age or older (Physical Activity and Public Health 2007). Basic dynamic and static balance exercises will be
reviewed and demonstrated. Documentation will be reviewed that supports how effective these exercise programs are and why they are successful in patient compliance. The physical and mental benefits that these three women experienced and the role that the exercise programs played in increasing their physical activity will be illustrated. Both exercise programs’ websites and contact information will be shared so that physicians can locate local classes for patient referrals. In any exercise program the client will eventually reach a plateau, however, implementing additional basic Age Management strategies can lead to positive outcomes. High Intensity Interval Training, Muscle Confusion/Periodization and Cross Training geared to seniors will be discussed in detail. Additional topics will include current dietary supplements available for increased muscle mass and recommended amounts and quality of protein for ensuring maximum gains in muscle tissue.
3:00 PM - 3:45 PM
Break - Visit Exhibits
3:45 PM - 4:45 PM
Complex Hormone Replacement Cases in Women
Neal Rouzier, M.D.
Director, The Preventive Medicine Clinics of the Desert, Palm Springs, CA
Lecture Description:
Prescribing hormones to women is easy 90% of the time. However it is the other 10% that requires skill, experience, insight, and command of the medical literature to appropriately treat complex cases. This lecture will review many complex cases and scenarios that will enable the experienced clinician to handle those difficult cases in women. A literature review will be provided to support why we do what we do in complex cases, as thorough understanding of the literature will enable one to understand how we handle complex cases and complications in women. In the end we will review the interventional data supporting early and continuous use of HRT to protect our brain and heart.
4:45 PM - 5:30 PM
Advanced Cases in Prevention: Integrating Hormone Therapies with Supplements, Diet, Exercise, Lifestyle and Stress Management to Improve Outcome
Erika Schwartz, M.D.
Member, Board of Trustees and Managers, SUNY-Downstate College of Medicine, Brooklyn, NY
President, Evolved Science
Lecture Description:
Four case studies have been chosen to reflect integration of hormones, diet, exercise, supplements, stress management and sleep in advanced prevention. Review of these cases is brought to the clinician in SOAP format and investigation of the various aspects of the case is undertaken with the audience’s participation. A stage wise process is followed to reflect how various courses of treatment affected the outcome and how to integrate troubleshooting modalities in specific areas of integrated care.
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
Preview of the AMMG Spring 2016 Track: Understand Your Genome - Integrating Genomics into Your Practice
Includes an Opportunity for Attendees to Obtain, GenoSequence and Interpret the Results of their Own Genetic Profile
Florence Comite, M.D. - Introduction
Erica Ramos, MS, LCGC, Sr. Staff Genetic Counselor, UYG Program, Illumina
Open to all attendees and includes a complimentary breakfast
Non-CME symposium sponsored by The Age Management Medicine Group (AMMG)
Session Held in Tower Ballroom just prior to Track #1
8:00 AM - 9:00 AM
Maximizing the Power of Microneedling
Edward M. Zimmerman, M.D.
Adjunct Associate Professor of Cosmetic Surgery, Touro University Nevada, School of Osteopathic Medicine, Henderson, NV
Medical Director & Owner, Las Vegas Laser & Lipo, Las Vegas, NV
Lecture Description:
Micro Fractional Collagen Stimulation, also referred to as microneedling/stamping/rollers, has been around since 1950. A procedure by which the body’s natural response to healing is used to increase the amount of extracellular matrix (such as collagen or elastin) in the skin, microneedling creates a fractional series of thousands of micro-channels, which allow for leakage of blood, serum and lymph in a controlled and temporary manner. These “injuries” are enough to initiate the “wound healing cascade.” This is an overview of current microneedling technology used for Collagen Induction Therapy in Skin and how CIT fits into the aesthetic practice.
9:00 AM - 10:00 AM
The Use of Platelet Rich Plasma (PRP) and Adipose Derived Regenerative Cells (ADRCs) in Aesthetic Medicine
Edward M. Zimmerman, M.D.
Adjunct Associate Professor of Cosmetic Surgery, Touro University Nevada, School of Osteopathic Medicine, Henderson, NV
Medical Director & Owner, Las Vegas Laser & Lipo, Las Vegas, NV
(This lecture is Non-CME)
Lecture Description:
PRP from whole blood is increasingly utilized to help heal joints and soft tissue. It has a number of uses in Aesthetic Medicine as well. Similarly, fat is a rich source of ADRCs which are used to enhance a variety of aesthetic procedures from microneedling for skin and scalp rejuvenation, to supporting the success of fat grafting and incisional and ablative aesthetic procedures. Additionally, autologous regenerative cells may be directly injected into traumatized tissue, organs and joints, in similar fashion to PRP, but with the possibility of enhanced positive results. IV supplementation of autologous cells may help with certain systemic issues and synergistically support bio-identical hormone replacement. A review of terminology and basic techniques for ADRC isolation and uses will be presented. Participants will be made aware of current and evolving FDA guidelines and limits for use of ADRCs in the U.S., as part of the practice of medicine.
10:00 AM - 10:15 AM
Break
10:15 AM - 10:45 AM
The Keys (Nutrition and Exercise) to Your Aesthetic Goals
Kevin M. Finnegan, M.S.
Director, Product Formulations, Cenegenics Global Health
Lecture Description:
The primary reason to eat right and exercise is to promote long lasting health and decrease the risk of disease. However, many patients are also looking for some side benefits including the potential to reach their absolute peak in body composition goals. Many times patients are constantly damaging their muscles and not repairing them with proper amounts of protein. Many times patients are cutting fats from their diet and losing the firmness in their skin. There are many reasons to exercise and eat properly but to achieve maximal health and reach your body composition goals, there needs to be a clearer balance in a program.
10:45 AM - 11:15 AM
Learn How to Use Social Media to Reach Aesthetic Patients and Fit Your Budget
Marcus Sanchez
Director Marketing, Rejuvapen, Jacksonville Beach, FL
(This lecture is Non-CME)
Lecture Description:
When businesses want to reach the masses, they no longer look to television, radio or print media like newspapers and magazines. Instead, they turn to social media networks to connect with consumers and other businesses, with surprisingly good results. The medical industry has been slow to embrace this method of communication. As a result, doctors, medical device manufacturers, medical institutions and companies may be losing out on a chance to connect with potential patients. Many doctors, hospitals and other medical institutions tend towards caution when it comes to entering the world of social media, and the majority of practitioners avoid social media altogether. Among the biggest concerns that medical practitioners and institutions have with the use of social media is the need to protect patient privacy and fears that entry into social media may compromise security. Another concern is that it would be necessary for doctors, hospitals and other healthcare providers to create a monitoring system to prevent employees from abusing the social media connection, and to ensure that information that is shared is factually correct and has a positive impact on the image and reputation of the institution. In addition to adding a virtual face to an otherwise faceless establishment, using social media allows quick communication between businesses and consumers. This is especially helpful for pharmaceutical companies, medical supply companies and other medical businesses. If there is
information to be shared—whether it’s for upcoming events or sales or for new inventory—there’s no better way to get the word out quickly without having to pay costly postage.
• How organizations can use this platform to alleviate damage to brand equity
• The importance of transparency
• Examples of how social media has fomented health care brand negativity
• How being proactive on social media can pay significant dividends
11:15 AM - 12:00 PM
Utilization of Carbohydrates for Physique & Performance Enhancement
Rudy M. Inaba
Director, Nutrition & Exercise, Cenegenics Elite Health
Instructor, AMMEF Certification Course
Lecture Description:
The application of carbohydrates is often one dimensional in age management programs. Most sedentary and overweight/overfat individuals will greatly benefit from carbohydrate restriction and regular exercise. When initial biometric and lifestyle milestones are met, exercise prescriptions are updated to stimulate further adaptation. Unfortunately, general carbohydrate restriction continues, regardless of individual physique and performance goals. In this lecture, we will discuss how to apply and utilize carbohydrates to help reach patients’ newfound physical aspirations and maximize performance.
12:00 PM - 1:30 PM
Lunch Break
12:00 PM - 1:00 PM
Telomere Biology Workshop: Pearls from 7 Years of Monitoring Patients on TA-65®
Presented by Joseph M. Raffaele, M.D.
Open to all attendees and includes a complimentary lunch
Non-CME symposium sponsored by T.A. Sciences
1:30 PM - 2:15 PM
Combination Treatment
Edward M. Zimmerman, M.D.
Adjunct Associate Professor of Cosmetic Surgery, Touro University Nevada, School of Osteopathic Medicine, Henderson, NV
Medical Director & Owner, Las Vegas Laser & Lipo, Las Vegas, NV
(This lecture is Non-CME)
Lecture Description:
Learn how to incorporate the many noninvasive procedures available in the office. Utilizing Botox and filler can create significant visual change in the patient's facial profile. Combine with that some skin resurfacing, all of which involves little to no downtime to the patient.
2:00 PM - 7:00 PM
Exhibits Open
2:15 PM - 3:00 PM
Growth Factors: Myth vs. Science
Bertica M. Rubio, M.D.
Medical Director, Antiaging Regenerative Medicine Clinic, Redlands, CA
Medical Advisor, Rejuvenate Image Restoration, Refine and AQ Skin Solutions
Lecture Description:
Growth factors: why are they so special? What do we look for to qualify the right ones for the condition we are treating? How do we place them into an aesthetic practice and why? Understand the importance of knowing the source of the gf in how a product is manufactured. Get the medical foundation to select the ideal gf combination to achieve the desired effect for your patient's condition. Expand your knowledge of how YOU can implement the use of gf into your Medical or Aesthetic practice.
3:00 PM - 3:45 PM
Break - Visit Exhibits
3:45 PM - 4:30 PM
Hidden Hormone Issues that Affect Your Skin Health
Sanjay Kapur, Ph.D., MBA
CEO, AYUMETRIX, Portland, OR
Lecture Description:
Skin health is a major concern, especially in aging women. It is no coincidence that the decline in hormone levels as people age parallels the decline in skin properties frequently associated with aging. Hormones are intrinsically involved with processes affecting the maintenance of skin health, such as collagen content, skin lipid levels, elasticity, wound healing, glycoaminoglycan content, and facial hair patterns. This program addresses the importance of hormones in skin wellness, but also cautions women and men seeking to reverse skin deterioration by using hormone replacement. Hormonal deficiencies can be identified with minimally invasive laboratory testing and treated with hormone replacement to improve overall health and wellness as well as to mitigate the effects of aging. However, hormone replacement should be done with appropriate monitoring to ensure physiological hormone levels are achieved. The irresponsible use of topical or systemic hormones for cosmetic purposes cannot be recommended, and it is important to understand the powerful effects of hormones throughout the body. The cosmetic and anti-aging industry is big business. Yet a major culprit for the skin thinning, wrinkling, and dryness associated with aging is the decline in hormones such as estrogen and progesterone in women, and testosterone in men. This program examines the relationship between hormones and skin properties and explores the effects of hormone replacement on some of the skin problems
associated with hormonal decline. While hormone replacement cannot be recommended solely for cosmetic purposes, proper monitoring of hormone levels in an aging population can help identify deficiencies that can be resolved with judicious hormone use, which may have the added benefit of improving skin wellness and thereby saving substantial costs in cosmetic treatments.
4:30 PM - 5:00 PM
Pre and Post Procedural Protocols
Marie Piantino, L.E.
President, Aesthetic Education Group LLC
Founder, American Academy of Medical Microneedling
(This lecture is Non-CME)
Lecture Description:
Provide the Physician with a complete care program and reduce recuperation time make it a” seamless service”. How to manage pigmentation pre and post? What helps thermal healing/peeling skin/microscopic perforation? Does your sunscreen burn post treatment ? We will discuss types of ingredients delivery systems and have to create the perfect post care kit for each patient. Can we use camouflage if so what do we look for?
5:00 PM - 5:30 PM
Panel of Experts with Q & A
Rudy M. Inaba
Director, Nutrition & Exercise, Cenegenics Elite Health
Instructor, AMMEF Certification Course
Edward M. Zimmerman, M.D.
Adjunct Associate Professor of Cosmetic Surgery, Touro University Nevada, School of Osteopathic Medicine, Henderson, NV
Medical Director & Owner, Las Vegas Laser & Lipo, Las Vegas, NV
Bertica M. Rubio, M.D.
Medical Director, Antiaging Regenerative Medicine Clinic, Redlands, CA
Medical Advisor, Rejuvenate Image Restoration, Refine and AQ Skin Solutions
Kevin M. Finnegan, M.S.
Director, Product Formulations, Cenegenics Global Health
Sanjay Kapur, Ph.D., MBA
CEO, AYUMETRIX, Portland, OR
5:30 PM - 7:00 PM
AMMG Welcome Reception
Open to all conference attendees, spouses and guests
Held in Conference Networking and Exhibits Center
7:00 AM - 7:45 AM
How to Build A Strong Age Management Business by Implementing Medical Weight Loss Into Your Practice
Kimball Lundahl, D.C., V.P. of Business Development
Open to all attendees and includes a complimentary breakfast
Non-CME breakfast symposium sponsored by Healthy Habits
8:00 AM - 8:05 AM
Opening Remarks
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
8:05 AM - 8:30 AM
Presentation of the Alan P. Mintz, M.D. Award for Clinical Excellence
8:30 AM - 9:15 AM
Cardiovascular Genomics: Is the Future of Cardiac Care Finally Here?
George C. Shapiro, M.D., FACC
Adjunct Assistant Professor Clinical Medicine, New York Medical College, Valhalla, NY
Founding Partner, Cenegenics, New York City
Member, AMMG Conference Planning Committee
Lecture Description:
Advanced Genomic testing and Gene Editing as it relates to the cardiovascular system will be discussed. Genes associated with: Early and late onset CAD, premature hemorrhagic stroke, cardio embolic stroke, ischemic stroke, atrial fibrillation, familial aortic aneurysms and dissection, coronary artery calcium, myocardial infarction, CIMT thickness and carotid plaques, hypertension, lipids including PCSK9, diabetes mellitus, inflammation, cardiomyopathies, arrhythmias, congestive heart failure, adverse drug reactions, clopidogrel, warfarin, will be reviewed and presented in a format so the office-based physician can utilize these new tools in their medical practice to prevent CVD and improve longevity. The Illumina Metabochip, GWAS Loci for CAD, Whole Genome Sequencing, Transcriptomics and the CRISPR-Cas9 tool for Gene Editing will also be reviewed.
9:15 AM - 10:00 AM
Featured Lecture - Management of Atrial Fibrillation in 2015: Why Age Matters
Win-Kuang Shen, M.D.
Professor of Medicine, Mayo Clinic College of Medicine, Rochester, MN
Chair, Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Phoenix, AZ
Lecture Description:
Dr. Shen will provide information on recognizing age-dependent changes in atrial electrophysiology and increased risk of atrial fibrillation and will describe pharmacokinetic and pharmacodynamic changes of antiarrhythmic drugs as a function of age. He will provide an update of the most advanced treatment strategies for atrial fibrillation.
10:00 AM - 10:45 AM
Break - Visit Exhibits
10:45 AM - 11:30 AM
Mitochondrial Agents in Cardiovascular Disease
Derrick M. DeSilva, Jr., M.D.
Chairman, AMMG Conference Planning Committee
Senior Attending Staff, Dept. of Medicine, Raritan Bay Medical Center, Perth Amboy, NJ
Teaching Faculty, JFK Medical Center, Edison, NJ
Lecture Description:
The mitochondria are the powerhouse of cells. If there is mitochondrial dysfunction there will be cellular dysfunction. This mitochondrial dysfunction may be one of the culprits in aging and it is well known that mitochondrial dysfunction does play a role in various disease states like cardiac dysfunction and could also play a role in neuro-degenerative diseases. CoQ10 is probably the best-known nutrient that helps support mitochondrial energy, but there are many others. We will review the other new cellular energy nutrients and how these nutrients play a role in the aging process, neuro-degenerative diseases and metabolic disorders. We will also review some of the genetic markers that may point to cellular dysfunction and how these genetic markers will influence how we treat patients today and in the future.
11:30 AM - 12:15 PM
The Relationship Between Heart-Brain Dynamics, Coherence, Optimal Health and Cognitive Function
Rollin McCraty, Ph.D.
Director of Research, HeartMath Research Center, Boulder Creek, CA
Professor, Florida Atlantic University, Boca Raton, FL
Lecture Description:
This presentation will cover the scientific background and clinical applications of a new approach to increasing patients’ capacity to self-regulate that has a wide range of healthcare applications, including blood pressure control, CHF, arrhythmias, cardiac rehabilitation, digestive system disorders, headaches, asthma, diabetes, epilepsy and a wide range of psychological conditions, including anxiety, ADHD, sleeplessness and depression. It will provide an overview of how the heart and brain dynamically interact and how the heart synchronizes the neural activity in the brain systems that underlie one’s ability to self-regulate energy expenditures, sustain resilience and perform optimally.
12:15 PM - 1:30 PM
Lunch Break - Visit Exhibits
12:15 PM - 1:15 PM
Physician Training and Certification in Age Management Medicine: Essential Qualifications and Knowledge for the Age Management Medicine Physician
Presented by Jeffrey P. Leake, M.D.
Open to all attendees and includes a complimentary lunch
Non-CME symposium sponsored by Cenegenics Elite Health
1:30 PM - 2:00 PM
Controversies About the Cholesterol Guidelines: Population vs Personalized Therapy
Ernst J. Schaefer, M.D.
Distinguished Professor & Senior Scientist, Human Nutrition Research Center on Aging, Tufts University, Tufts University School of Medicine, Boston, MA
Director, Cardiovascular Research Clinic, Boston, MA
Chief Medical Officer, Boston Heart Diagnostics, Framingham, MA
Lecture Description:
Prior guidelines for the management of elevated blood cholesterol have focused on getting serum low density lipoprotein cholesterol (LDL-C) levels to < 100 mg/dL in high risk patients, and to < 70 mg/dL in patients with cardiovascular disease (CVD) and/or diabetes. Newly released guidelines focus on four group aged 40 - 75 years as candidates for statin therapy after lifestyle modification: 1) patients with established CVD, 2) patients with diabetes, 3) patients with an LDL-C value > 190 mg/dL, and 4) patients with a 10 year risk of CVD > 7.5% [Stone N et al. NJ et al. Circulation. 2014;129 (Suppl 2):S1-S45.)]. CVD risk assessment over 10 years is carried by accessing the website www.myamericanheart.org/CVriskcalculator and using age, gender, race, systolic blood pressure, treatment for high blood pressure, diabetes, smoking, total cholesterol, and high density lipoprotein cholesterol (HDL-C) (Goff DC Jr, et al Circulation.2014;129 (Suppl 2):S49-73). No goals for LDL-C lowering were provided except to get LDL-C reductions of > 50% in patients with CVD and LDL-C values > 190 mg/dL using intensive statin therapy (atorvastatin 40 - 80 mg/day or rosuvastatin 20 - 40 mg/day) or by about 30% in patients with diabetes or at high CVD risk with moderately intensive statin therapy. In my view and in those of the National Lipid Association, the International Atherosclerosis Society, and the European Atherosclerosis Society, the lack of clear targets is a shortcoming of the new
guidelines, as is the lack of guidance with regard to patients > 75 years of age, and the use of non-statin medications. Recent randomized trials indicate that ezetimibe and fish oil both add CVD risk reduction benefit in CVD patients on top of statin therapy (IMPROVE-IT, JELIS), as does fenofibrate in diabetic patients (ACCORD) and niacin in CVD patients (AIM HIGH) provided they have HDL-C < 35 mg/dL and triglyceride levels > 200 mg/dL. The guidelines also do not take family history, lipoprotein(a), small dense LDL, HDL particles, homocysteine, or inflammation markers (C reactive protein, lipoprotein associated phospholipase A2, and myeloperoxidase) into account. In addition non cholesterol sterols and genetic markers (SLCO1B1, MTHFR) inform us about more optimal personalized therapy. The current guidelines have significant shortcomings, and providers need to do their best to incorporate newer information in order to optimize therapy for CVD prevention.
2:00 PM - 2:45 PM
Hormones and Cardiovascular Disease
Gary Donovitz, M.D., FACOG, FRSM
Founder and CEO, BioTE Medical, Irving, TX
Founder and President, Institute for Hormonal Balance
Lecture Description:
Hormones in men and women are often thought of for symptoms of the menopause and andropause. Whereas hot flashes, vulvovaginal atrophy and erectile dysfunction are certainly bothersome problems, cardiovascular disease remains the number 1 killer of men and women. For 20 years, big Pharma has attempted to brainwash physicians and patients into believing that statins were the key to reducing cardiovascular disease, but their success is limited and often detrimental. Bioidentical hormone therapy has both a protective effect and a therapeutic effect on cardiovascular disease. Maintaining optimal levels of hormones can increase blood flow, reduce plaque formation, and decrease inflammation in the coronary arteries. Their effect on serum lipids is also positive. So this lecture is intended to offer a path whereby we can begin reducing cardiovascular disease in both men and women, reducing mortality and improving quality of life.
2:45 PM - 3:15 PM
Break - Visit Exhibits
3:15 PM - 4:00 PM
Oral Pathogens and Coronary Heart Disease
Thomas E. Levy, M.D., J.D.
Consultant, Riordan Clinic & LivOn Laboratories
Staff, Memorial Hospital, Colorado Springs, CO
Lecture Description:
Inflammation is now accepted as the initiating common denominator in the evolution of coronary atherosclerosis. In spite of this, there has not been much investigation into why the inflammation in the endothelium of the coronary artery develops or presents in the first place. However, the dental and medical literature has recognized for some years now that there is a strong correlation between periodontal disease and coronary artery disease. It now appears that this is a causal relationship and not just a correlation. Multiple researchers have now established that the DNA of oral pathogens can be detected in the vast majority of patients with coronary artery disease, and not just those with periodontal disease. Root canal-treated teeth, pulpal infection, and apical periodontitis have been found to have typical pathogen/DNA profiles, and these profiles are being seen in greater than 90% of coronary atheromas. These profiles are now documented to be routinely present in the coronary arterial wall, the associated plaques, and in even higher concentration in the clots that acutely form and cause myocardial infarctions. Furthermore, very recent evidence is documenting the same profiles in the vasculature involved in strokes, and even in the pericardial fluid found at autopsy in patients with coronary artery disease. The emphasis of the presentation will be to present the documentation of these assertions, discuss the pathophysiology, and to make it clear that no myocardial
infarction patient has been properly evaluated and treated in the absence of proper dental evaluation and treatment as well.
4:00 PM - 4:45 PM
Erectile Dysfunction is Endothelial Dysfunction: Understanding the Symptoms that Lead to Heart Disease
Nathan S. Bryan, Ph.D.
Professor, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
Lecture Description:
Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient to allow satisfactory sexual intercourse. Affecting tens of millions of men worldwide, ED is growing rapidly, and its prevalence is expected to double over the next 20 years. Despite its growing incidence, which is partly a result of the sexual awakening stimulated by the new pharmacologic therapies, ED remains underdiagnosed, with millions of men worldwide never coming to medical attention because of the sensitivity of the issue. However, ED is now considered a symptom of another ED, endothelial dysfunction or the inability of endothelial cells to generate sufficient nitric oxide (NO). NO is a multifunctional signaling molecule, intricately involved with maintaining a host of physiological processes including but not limited to neural communication and the regulation of tissue perfusion and blood pressure. Loss of NO function is one of the earliest indicators or markers of disease. Experimental and clinical studies provide evidence that defects of endothelial NO production, referred to as endothelial dysfunction manifests firstly as erectile dysfunction in both men and women. Understanding that erectile dysfunction is not just a socially inconvenient condition but rather a symptom of a very serious underlying condition of endothelial dysfunction will allow physicians to implement strategies to restore NO production and vascular function to prevent progression of cardiovascular disease.
Thirty plus years after its discovery and over 12 years since a Nobel Prize was awarded for its discovery, there have been no hallmark therapeutic breakthroughs. We will review the current state of the science surrounding nitric oxide in the etiology of a number of different disease states and reveal the latest technology to safely and effectively restore nitric oxide in patients. The audience will learn the challenges and opportunities that exist in understanding NO homeostasis in their patients and how this may translate into better management of their patients.
4:45 PM - 5:30 PM
Latest Advances in Lipid Testing and Inflammatory Markers
Cesar M. Pellarano, M.D.
Preventive Cardiologist, Miami, FL
President, Founding Partner and Chief Medical Officer, Hillstar Health LLC, Miami, FL
Lecture Description:
It is well documented that up to 50% of patients with heart attacks have normal cholesterol levels. Over the years we have seen the development of advanced lipid panels, lipid particle size and lipid particle numbers as part of the evaluation. These have been accomplished by different methodologies. However, now we can expand on this knowledge by specific analysis of the HDL with the HDL Map technique. The same can be said of the LDL with the Cholesterol Balance Test. The HDL Map tells us the quality of the patient’s HDL, but more importantly, how we can modify it to benefit the patient. The Cholesterol Balance Test gives us the information we need to tell a patient how they handle their cholesterol, and more importantly, how to direct their therapy. Inflammatory markers are extremely important in preventing Cardiovascular Disease. After all, Cardiovascular Disease is, by definition, an inflammatory disease. In my lecture we will point out how to use these markers, and how to modify them to benefit our patients.
7:00 AM - 7:45 AM
Optimizing the Legal Use of Growth Hormone
Presented by Mark Gordon, M.D.
Open to all attendees and includes a complimentary breakfast
Non-CME symposium sponsored by University Specialty Drugs
8:00 AM - 8:50 AM
Featured Lecture – The Practical Deployment of Precision Medicine
Robert J. Hariri, M.D., Ph.D.
Adjunct Associate Professor of Pathology, Mt. Sinai School of Medicine, New York, NY
Founder and Executive Chairman, MYOS Corporation, Cedar Knolls, NJ
Co-Founder and Vice-Chairman, Human Longevity, Inc., San Diego, CA
Founder and Chairman, Celgene Cellular Therapeutics, Summit, NJ
Lecture Description:
What can you offer patients today that provides them access to 21st Century Medicine?
8:50 AM - 9:40 AM
Clinical Strategies to Implement Precision Medicine in an Age Management Practice
Florence Comite, M.D.
CEO & Founder, Comite Center for Precision Medicine, New York, NY
Member, AMMG Conference Planning Committee
Lecture Description:
President Obama’s 2015 State of the Union announcement heralding a Precision Medicine Initiative introduced the nation to an emerging multi-disciplinary field in which a physician evaluates an individual, with extreme precision and at the cellular level, to detect, prevent and reverse disease years, even decades, before symptoms manifest. What has not been on the main agenda, however, is where, how, and when the physician can implement Precision Medicine into current practice, thereby offering a comprehensive analysis of present-day health and prediction of an individual’s health trajectory. Precision Medicine for Age Management flips the traditional disease-centric model of medicine to focus on sustaining health before disorders of aging strikes. It is possible to alter genetic wiring by changing genomic expression of disease, thereby reversing diabetes, heart disease, stroke, osteoporosis and cancer associated with aging. Chronic diseases such as cardiovascular disease, diabetes, cancer, and degenerative disorders are generally multifactorial, and arise due to numerous triggers, from lifestyle to family history to the microbiome, driven by metabolic and hormonal factors among other variables. Genes are constantly being activated and silenced based on our environment—their expression is not written in stone. This means that genes are not necessarily destiny, and interventions can potentially change whether genes are triggered, a field called epigenetics. Employing genomics,
epigenetics, metabolomics, proteinomics - these specialized fields and more – is key to understanding each person at the cellular level. Individuals undergo extensive analysis which identify biomarkers and metrics. Precisionists collect detailed family background and lifestyle measures that deepen an appreciation of both current and future health. Precision Medicine allows for precise personalized guidance with respect to subsequent diagnostic tests and procedures as well as interventions. The ultimate goal as a clinician: to thwart disease and prolong health. Precision Medicine Strategies in Age Management ultimately achieve the optimization of all health measures, a sustained vitality for life, and, truly, the potential for a health span to match a life span.
9:40 AM - 10:10 AM
Break - Visit Exhibits
10:10 AM - 11:10 AM
Featured Lecture - Demystifying Liquid Biopsies: How Cutting-edge Diagnostics are Generating New Insights for Therapy Selection and Resistance Monitoring in Cancer
Murali Prahalad, Ph.D.
President & CEO, Epic Sciences
Advisory Board, Department of Biomedical Informatics, Harvard Medical School
Lecture Description:
Over the past several years, the advent of next generation sequencing (NGS) has shed light on cancer as a disease of the DNA. What is increasingly being appreciated is that cancer is not a disease of genomic “averages” but a disease of multiple clonal species that coexist in patients simultaneously and evolve in response to therapeutic selective pressure. This session will view the challenges posed by cancer’s cellular heterogeneity and will explore how advances in the identification and characterization of circulating tumor cells are generating radically new insights into the disease. It will explore how these insights will change how we think about NCCN guidelines to how we can evolve towards a world of real-time, personalized matching of combination therapies to a patient’s individual cancer profile.
11:10 AM - 12:00 PM
The Latest in Cancer Screening
D. James Morre, Ph.D.
Emeritus Professor of Medicinal Chemistry, Purdue University, West Lafayette, IN
CEO & Director of Research, MorNuCo, Inc., West Lafayette, IN
Editorial Boards, Biochimica et Biophysicia Acta Biomembrane Reviews and Nonlinerarity in Biology, Toxicology and Medicine
Edwin N. Lee, M.D., FACE
Assistant Professor of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL
Founder, Institute for Hormonal Balance
Member, AMMG Conference Planning Committee
Lecture Description:
Approximately 15 million Americans have cancer. However, when some cancers are diagnosed, it is usually too late to treat. For the past 50 years, we have been at war with cancer - a war we are losing, thanks to the current standard therapy of chemotherapy, radiation, and/or surgery. Rather, the way to win this war is by preventing cancer, as in this combined talk with Dr. Lee, who will be discussing the root causes of cancer. Dr. Morre, the sole discover of the ENOX proteins, will be lecturing on the spectrum of the Enox protein. The ENOX2 protein will be discussed as a very early marker for over 20 cancers. Some examples of the cancers that can be detected are: prostate, breast, colon, lung. ovarian, and pancreatic. This revolutionary test will be the game-changer in early detection of cancer and the management of cancer patients.
12:00 PM - 1:30 PM
Lunch Break - Visit Exhibits
12:00 PM - 1:00 PM
Sub-Cutaneous Hormone Pellet Therapy: Alternative Medicine or an Alternative to Bad Medicine
Gary S. Donovitz, M.D.
Open to all attendees and includes a complimentary lunch
Non-CME symposium sponsored by BioTE Medical
1:30 PM - 2:15 PM
Clinical & Translational Pharmacogenomics
Joseph P. Kitzmiller, M.D., Ph.D.
Assistant Professor, College of Engineering, College of Medicine, The Ohio State University, Columbus, OH
Medical Supervisor, Ohio Clinical Trials & Premier Laser Spa
Physician, Gnome Diagnostics
Lecture Description:
With President Obama’s launch of the Precision Medicine Initiative in early 2015 the era of Personalized Medicine has officially commenced in the U.S. market, and words like pharmacogenomics and genetic risk score are becoming common vernacular. As physicians practicing age management medicine, we offer a proactive, preventative approach to healthcare for our aging patients in order to improve and preserve optimal human function and quality of life. Personalized medicine is certainly a significant component of optimal medical management, and although pharmacogenomic testing currently has only limited implications for hormone-replacement therapy, many of our patients are likely to be on medications for which pharmacogenomic testing is applicable. Genetics account for much of the variability in our patients’ responses to drug therapies. This presentation offers the clinician an up-to-date overview of pharmacogenomic testing, briefly discussing implications and limitations of emerging validated tests relevant to the use of many commonly prescribed medications (e.g., warfarin, clopidogrel, statins, tamoxifen, codeine, and psychotropic drugs). The emerging future role of pharmacogenomics and personalized medicine will also be discussed.
2:15 PM - 3:00 PM
Genetic Screening: A Tool for Better Health With Age
Matthew Pratt-Hyatt, Ph.D.
Associate Laboratory Director, Great Plains Laboratory, Lenexa, KS
Lecture Description:
Genetic testing has long been considered the “future of medicine.” Are we living in the future or is the future still “almost here”? New advances in sequencing technology have not only increased the amount of information available to patients, but have dramatically decreased the cost of testing. However, it may be difficult to determine which genetic test panels to request or which specific genes to test. Most genetics tests available on the market monitor for the presence of Single-Nucleotide Polymorphisms (SNPs), which are small changes in the genetic code that could lead to chronic diseases. In this presentation, Dr. Pratt-Hyatt will discuss several enzyme groups that are important to the aging patient population. These enzyme groups include the P450 drug metabolizing enzymes, the transporter enzymes, cholesterol biosynthesis enzymes, oxidation signaling enzymes, and detoxification enzymes. These enzymes determine how well the patient can metabolize drugs, transport drugs into the cell, maintain integrity of the brain, and mitigate damage from oxidative stress. An understanding of the genetic mutations in these key groups allows the physician to create a customized treatment plan specific to their individual patients’ needs. Knowing the mutations in these enzyme groups will assist physicians in understanding dosing of medicine, what types of drugs may have harmful interactions, the distribution of drugs throughout the body, if cholesterol abnormalities could influence the
brain, and if the key oxidation stress detection enzymes are functioning properly, all of which are important for the cells to avoid the deleterious effects of age.
3:00 PM - 3:45 PM
Break - Visit Exhibits
(exhibits close 4:00 PM)
3:45 PM - 4:40 PM
Nutrigenomics: Reshaping the Nutrition Landscape
Christine Houghton, B.Sc., D.C., R.Nutr., Ph.D. Cand.
Ph.D. Researcher, School of Human Movement Studies, University of Queensland, Brisbane, Australia
Co-author, Educational Program Translational Nutrigenomics, Manuka Science, Durban, South Africa
Managing Director, Cell-Logic Pty Ltd, Queensland, Australia
Lecture Description:
To the clinician embracing Nutritional, Integrative and Functional Medicine, the concept of Personalised Medicine is not new. As long ago as 1956, Dr. Roger Williams introduced the principle of Biochemical Individuality, heralding a new era in our understanding of disease etiology and the role of nutrients as intervention tools. Remarkably, Dr. Williams recognised that nutritional status can influence the expression of genetic characteristics, even though at the time no tools were available to determine biochemical individuality. Fast-forward six decades and we witness an explosion of research in this field, often with conflicting findings and uncertain interpretation. The completion of the Human Genome Project in 2003 sparked hope that otherwise incurable diseases might be cured by the identification of the specific genes responsible for common diseases. Perhaps quite predictably, such a simplistic model explains the etiology of just a few diseases. However, a more eclectic view reveals the enormous value of being able to determine a patient’s genotype as it relates to the core biochemical processes which underpin the development of disease, especially chronic disease. Out of this awareness have been born the companion disciplines of Nutrigenetics and Nutrigenomics. These disciplines are a melding of elements of the sciences of Biochemistry, Nutrition and Genetics as well as the many ‘omics’ which have emerged; as a result, developing clinical competence is not an easy task.
Although each of us possesses potentially hundreds of ‘at risk’ gene variants, the challenge lies in knowing how to interpret the pattern of SNPs which a nutrigenetic report may present. Whilst contemplating the role that nutrigenetics and nutrigenomics might play in their own clinical practices, clinicians have been exposed to the plethora of companies providing nutrigenetics testing, each with a range of genes for which polymorphisms exist. The interpretive support offered by the accompanying reports is necessarily limited and many clinicians lack the confidence to involve themselves further. The purpose of this presentation is to outline the scope of practice that these emerging disciplines can offer. In so doing, we highlight a number of the genes for which significant interpretive data exist. Using case studies, we outline how a clinician can incorporate nutrigenetic and nutrigenomic principles to address the factors that underpin chronic disease and age-related disorders. Embracing Nutrigenomics principles has indeed the potential to reshape the nutrition landscape.
4:40 PM - 5:30 PM
Precision Medicine: The Role of Individualizing Recommendations for a Nutritional and Detoxification Program
Sangeeta Pati, M.D., FACOG
Medical Director, SaJune Institute for Restorative and Regenerative Medicine, Orlando, FL
Board Certified, American Board of Obstetrics and Gynecology
Diplomat, Anti-Aging & Regenerative Medicine
Lecture Description:
When developing a program that addresses nutrition and/or toxins precisely, it is important to be able to individualize the program to the specific conditions, symptoms and nutritional/ toxin status of the patient. There are those principles that may apply to all and those that apply specifically to the individual, either based on their condition or their genetic predispositions. This individualization becomes critical when one recognizes that nutrients and toxins have epigenetic control on gene expression. In this lecture I will cover how you approach the individual program in a practical manner. Specific areas that will be covered include:
• What are some concrete examples of nutrients and toxins that affect gene expression?
• How does the micro-biome play into this picture?
• What are some practical ways to assess the nutritional status and toxic load of the individual?
• What are some general nutrition/detoxification principles that may apply universally to most people?
• How does one utilize the specific nutritional measurements and toxic status of a patient to individualize the program?
The data and principles in this lecture include the clinical experience applied to over 10,000 patients over 10 years. These will be shared through practical case presentations.
7:00 AM - 7:45 AM
Physicians Liability Insurance in the Specialty of Age Management Medicine: Are you paying too much?
John Rush, M.D., FACEP, MBA, MHA
Open to all attendees and includes a complimentary breakfast
Non-CME breakfast symposium sponsored by Longevity Physicians Insurance (LPI)
8:00 AM - 9:00 AM
Molecular Hydrogen: Therapeutic and Medical Applications
Tyler W. LeBaron
Adjunct Instructor of Physiology, Department of Biology, Brigham Young University-Idaho, Rexburg, ID
Executive Director, Molecular Hydrogen Institute
Lecture Description:
Molecular hydrogen (H2 gas) appears to be a biological signaling molecule similar to nitric oxide (NO*), carbon monoxide (CO), and hydrogen sulfide (H2S) with marked therapeutic potential. Over 400 scientific articles have been published since the 2007-pioneering work on hydrogen gas that confirmed hydrogen’s therapeutic effect in Nature Medicine. These articles along with 40+ human studies have shown molecular hydrogen to be therapeutic in essentially every organ of the human body and in 150 different human disease models. The safety of hydrogen gas in humans has been studied immensely since its widespread use in deep sea diving to prevent decompression sickness back in 1941. This medical gas has marked therapeutic potential in the field of disease prevention, anti-aging and longevity. H2 can easily diffuse through the cell membranes and intercellular compartments not only because it is the smallest molecule in the universe, but it is also electrically neutral and hydrophobic. H2 selectively scavenges the cytotoxic hydroxyl radicals (*OH) without eliminating the beneficial signaling molecules (e.g. H2O2, NO*, O22-, etc.). It can also stimulate the Nrf2 pathway leading to increased endogenous antioxidants including glutathione, superoxide dismutase, catalase, etc. Lastly, the cell modulating property of H2 affords it with remarkable anti-inflammatory, anti-allergy, anti-apoptotic, and anti-aging benefits. There are many methods of H2 administration, including H2 inhalation,
injection of H2-rich saline, ingestion of H2-rich water, and consumption of fibers that are metabolized by intestinal flora to produce H2 gas. The high safety profile, ease of use, and remarkable therapeutic efficacy of H2 therapy, make its use paramount for anyone in the field of anti-aging medicine.
9:00 AM - 10:00 AM
Stem Cell Therapy for Cardiovascular Disease, Initial Results in CHF and PAD
Ernst R. Schwarz, M.D., Ph.D.
Professor of Medicine, Cedars Sinai Medical Center at UCLA
Study co-authors: Karen Mulholand Angelus, Olivia Biswas, Kristin Comella
Lecture Description:
Cellular regenerative therapy has evolved in recent years as a repair strategy to address tissue damage formerly considered to be irreversible. Several international studies since 2000 have shown beneficial results using different types of stem cells derived either from bone marrow, adipose tissue or the heart that were administered either directly intramyocardialy, intravenously, or intracoronarily with promising results in regard to improved perfusion, contractility and scar reduction in patients with ischemic cardiomyopathy and congestive heart failure. In addition, cellular therapy in patient with severe peripheral arterial disease has demonstrated anecdotal results with improved perfusion secondary to angiogenesis, tissue repair and salvaged legs by avoiding amputations. We present initial data on the very first U.S. hospital based stem cell therapy clinic in patients with congestive heart failure, coronary artery disease, peripheral artery disease and erectile dysfunction with regard to improved functional capacity and clinical outcomes.
10:00 AM - 10:30 AM
Break
10:30 AM - 11:15 AM
Methods and Case Studies of Longevity and Optimization of Health in an Integrative Internal Medicine Practice
Dushyant Viswanathan, M.D., ABIM, ABoIM, AACE
Medical Director, The Columbia Center for Integrative Medicine, Columbia, MD and Woodland Hills, CA
Compare and Contrast Integrative and Conventional Medical Models of Age Management Medicine
Lecture Description:
This lecture will articulate background evidence, theoretical framework, methods, and results of an integrative internal medicine practice specializing in longevity and optimization of health. Background evidence will explore therapeutic impact of nutrition, hormone therapies, micronutrient therapies, lifestyle practices, the clinical use of yoga, and the science of connection. Theoretical framework will articulate the translation of the background evidence into real-world clinical situations in the workflow of the medical practice. Methods that will be delineated involve specific customized medical programs and lifestyle practices which lead to measurable objective and subjective clinical improvement in targeted areas (i.e. bone density, exercise capacity, quality of life, serologic data, organ function, capacity for mobility, symptom scores). Our discussion of results will highlight a particular case of a 55 year old woman who presented with certain symptoms, underwent assessment, started therapeutic programs, resolved symptoms, and moved towards longevity and optimization of health measured by improved subjective quality of life, improved bone density, resolution of autoimmune pathology, and demonstration of improved cardiac, adrenal, endocrine, and gastrointestinal health. It is our hypothesis that such a model of medical practice will lower the human and financial burden of chronic illness, and improve the quality of experience of our fellow man.
11:15 AM - 12:00 PM
The Conventional Model: Methods in Longevity and Optimization of Health
Bhavesh K. Patel, M.D.
Founder and CEO, Cenegenics, Chicago, IL
Compare and Contrast Integrative and Conventional Medical Models of Age Management Medicine
Lecture Description:
This lecture will examine a more conventional approach to Age Management Medicine which uses extensive diagnostic testing, individualized patient treatment plans incorporating fitness, nutrition, weight control and Hormone Therapy if indicated. Although this model is considered more conventional, by incorporating fitness and an array of nutritional supplements it may not totally meet the conventional strict criteria of “mainstream” however in this industry over time these protocols are becoming more commonplace.
12:00 PM - 12:30 PM
Q & A Compare and Contrast Integrative and Conventional Models of Age Management Medicine
Dushyant Viswanathan, M.D., ABIM, ABoIM, AACE
Medical Director, The Columbia Center for Integrative Medicine, Columbia, MD and Woodland Hills, CA
Bhavesh K. Patel, M.D.
Founder and CEO, Cenegenics, Chicago, IL
12:30 PM - 1:15 PM
Stem Cells as Possible Treatment for ED in the Setting of Radical Prostatectomy and Radiation and Diabetes: Understanding of the Technique for Intracavernosal Injection with Stem Cells
Carlos Mercado, M.D.
Medical Director, EternaMD Medical Rejuvenation Center, Lake Mary, FL
CEO & Medical Director, Stem Cells MD
Lecture Description:
ED (Erectile Dysfunction) affects 10 percent of the population worldwide. In 1995 it was estimated that 152 million were affected by ED. It is estimated that by 2025 352 million of population worldwide will be affected. Currently there is not available treatment that can restore or regenerate the tissues in the corpus cavernosum or arterial system that will cure the ED. A 20 percent failure rate with present therapies and high rate of drop out in patients with ED due to Radical Prostatectomy and Post Radiation. Testosterone Replacement is the only independent risk factor that might help Endothelial dysfunction and consequently ED. Adipose tissue is abundant and easy to collect from a miniliposuction. The procedure consists in collecting a lipoaspirate of 60 ml. No general anesthesia is required. It is an outpatient procedure. Adipose Tissue is processed using collagenase enzyume. SVF (Stromal Vascular Fraction) is isolated. Blood is obtained through a venipuncture. PRP (Platelet Rich-Plasma) is obtained. The SVF is suspended is PRP. The mixture is injected into the Corpus Cavernosum using our designed protocol for injection into the Corpus Cavernosum. Two types of patients: 1- DM 2- ED due to Prostatectomy and Radiation. Patients filled out the Intensity Score questionnaire before and after procedure. Both reported better erections in the morning, firmer, with better response to PDI5 inhibitors for which they were not responders prior to the treatment. This might be due to
stem cells to regenerate Corpus Nerve and Endothelial cells enhancing the Nitric Oxide production and then have the PDI5 inhibitors to work.
Complications: None. The IC injection of a suspension of SVF in PRP appears promising in ED patients due to DM and Prostatectomy and Radiation in which at present there is no a CURE and they have a high rate of failure to PDI5 inhibitors. The procedure is done as outpatient and requires no general anesthesia. The potential to treat diabetes as early as diagnosed might be a possibility since lower fasting glucose levels and improvement in HbA1C were noticed. More studies are in need.
|
 |
|